Recombinant Human ECE-1 Protein, CF | R&D Systems 1784-ZN product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ECE-1 Protein, CF

catalog :

1784-ZN

quantity :

10 ug

price :

339 USD

citations: 6

Reference
Chen A, Tully T. A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P. Neurobiol Dis. 2018;114:153-163 pubmed publisher
Miners J, Love S. Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies. J Neurochem. 2017;141:275-286 pubmed publisher
Palmer J, Baig S, Kehoe P, Love S. Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta. Am J Pathol. 2009;175:262-70 pubmed publisher
Roosterman D, Kempkes C, Cottrell G, Padilla B, Bunnett N, Turck C, et al. Endothelin-converting enzyme-1 degrades internalized somatostatin-14. Endocrinology. 2008;149:2200-7 pubmed publisher
Padilla B, Cottrell G, Roosterman D, Pikios S, Muller L, Steinhoff M, et al. Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol. 2007;179:981-97 pubmed
Miners J, Verbeek M, Rikkert M, Kehoe P, Love S. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J Neurosci Methods. 2008;167:229-36 pubmed

product information

brand :

R&D Systems

master code :

1784-ZN

SKU :

1784-ZN-010

product name :

Recombinant Human ECE-1 Protein, CF

description :

The Recombinant Human ECE-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ECE-1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ECE-1

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, NaCl and ZnCl2.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

115 kDa, reducing conditions

theoretical molecular weight :

79 kDa

gene symbol :

ECE1

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (Catalog # ES005 ). The specific activity is 2,500 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1784-ZN

accessionNumbers :

P42892

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human ECE-1 protein Gln90-Trp770, with an N-terminal signal peptide, 10-His tag and Val

2020 USD :

339

2021 USD :

339 USD

alt names :

EC 3.4.24, EC 3.4.24.71, ECE, ECE1, ECE-1, endothelin converting enzyme 1, endothelin-converting enzyme 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.