Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF | R&D Systems 177-IR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

catalog :

177-IR

quantity :

100 ug

price :

349 USD

citations: 3

Reference
Teng Y, Young J, Edwards B, HAYES P, Thompson L, Johnston C, et al. Diverse human VH antibody fragments with bio-therapeutic properties from the Crescendo Mouse. N Biotechnol. 2020;55:65-76 pubmed publisher
Liu S, Dakin L, Xing L, Withka J, Sahasrabudhe P, Li W, et al. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016;6:30859 pubmed publisher
Liu S, Desharnais J, Sahasrabudhe P, Jin P, Li W, Oates B, et al. Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide. Sci Rep. 2016;6:26071 pubmed publisher

product information

brand :

R&D Systems

master code :

177-IR

SKU :

177-IR-100

product name :

Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

description :

The Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-17RA/IL-17R

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

100 kDa, reducing conditions

theoretical molecular weight :

60 kDa (monomer)

gene symbol :

IL17RA

details of functionality :

Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.03-0.1 µg/mL in the presence of 10 ng/mL recombinant human IL-17.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

177-IR

accessionNumbers :

Q96F46

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human IL-17 RA/IL-17 R protein Human IL-17 RA/IL-17 R (Leu33-Trp 320) Accession # Q96F46 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

349

2021 USD :

349 USD

alt names :

CD217, CD217 antigen, Cdw217, CDw217interleukin 17 receptor, hIL-17R, IL-17 R, IL-17 RA, IL-17 receptor A, IL17RA, IL-17RAMGC10262, IL17Rinterleukin-17 receptor A, interleukin 17 receptor A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.