Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF | R&D Systems 177-IR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

catalog :

177-IR-100

quantity :

100 ug

price :

443 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Goedken E, Argiriadi M, Dietrich J, Petros A, Krishnan N, Panchal S, et al. Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep. 2022;12:14561 pubmed publisher
Teng Y, Young J, Edwards B, HAYES P, Thompson L, Johnston C, et al. Diverse human VH antibody fragments with bio-therapeutic properties from the Crescendo Mouse. N Biotechnol. 2020;55:65-76 pubmed publisher
Liu S, Dakin L, Xing L, Withka J, Sahasrabudhe P, Li W, et al. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep. 2016;6:30859 pubmed publisher
Liu S, Desharnais J, Sahasrabudhe P, Jin P, Li W, Oates B, et al. Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide. Sci Rep. 2016;6:26071 pubmed publisher

product information

brand :

R&D Systems

master code :

177-IR

SKU :

177-IR-100

product name :

Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

unit size :

100 ug

seo description :

The Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-17RA/IL-17R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

100 kDa, reducing conditions

theoretical molecular weight :

60 kDa (monomer)

gene symbol :

IL17RA

details of functionality :

Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.03-0.1 ╡g/mL in the presence of 10 ng/mL recombinant human IL-17.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q96F46

applications :

Bioactivity

source :

NS0-derived Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

USD :

443 USD

alt names :

CD217, CD217 antigen, Cdw217, CDw217interleukin 17 receptor, hIL-17R, IL-17 R, IL-17 RA, IL-17 receptor A, IL17RA, IL-17RAMGC10262, IL17Rinterleukin-17 receptor A, interleukin 17 receptor A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage