Recombinant Human Lipocalin-2/NGAL Protein, CF | R&D Systems 1757-LC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Lipocalin-2/NGAL Protein, CF

catalog :

1757-LC

quantity :

50 ug

price :

339 USD

citations: 13

Reference
An S, Raju I, Surenkhuu B, Kwon J, Gulati S, Karaman M, et al. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019;: pubmed publisher
Zhao Y, Xia Q, Liu Y, Bai W, Yao Y, Ding J, et al. TCF7L2 and EGR1 synergistic activation of transcription of LCN2 via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma cells. Cell Signal. 2019;55:8-16 pubmed publisher
Parmar T, Parmar V, Perusek L, Georges A, Takahashi M, Crabb J, et al. Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration. J Immunol. 2018;200:3128-3141 pubmed publisher
Yan C, Yuanjie T, Zhengqun X, Jiayan C, Kongdan L. Neutrophil Gelatinase-Associated Lipocalin Attenuates Ischemia/Reperfusion Injury in an In Vitro Model via Autophagy Activation. Med Sci Monit. 2018;24:479-485 pubmed
Gomez Chou S, Swidnicka Siergiejko A, Badi N, Chavez Tomar M, Lesinski G, Bekaii Saab T, et al. Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment. Cancer Res. 2017;77:2647-2660 pubmed publisher
Wang B, Chen G, Li J, Zeng Y, Wu Y, Yan X. Neutrophil gelatinase-associated lipocalin predicts myocardial dysfunction and mortality in severe sepsis and septic shock. Int J Cardiol. 2017;227:589-594 pubmed publisher
Saha P, Yeoh B, Singh R, Chandrasekar B, Vemula P, Haribabu B, et al. Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases. PLoS ONE. 2016;11:e0156811 pubmed publisher
Cantaluppi V, Dellepiane S, Tamagnone M, Medica D, Figliolini F, Messina M, et al. Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors. PLoS ONE. 2015;10:e0129279 pubmed publisher
Drew B, Hamidi H, Zhou Z, Villanueva C, Krum S, Calkin A, et al. Estrogen receptor (ER)Î±-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015;290:5566-81 pubmed publisher
La Manna G, Ghinatti G, Tazzari P, Alviano F, Ricci F, Capelli I, et al. Neutrophil gelatinase-associated lipocalin increases HLA-G(+)/FoxP3(+) T-regulatory cell population in an in vitro model of PBMC. PLoS ONE. 2014;9:e89497 pubmed publisher
Paton C, Rogowski M, Kozimor A, Stevenson J, Chang H, Cooper J. Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women. Obesity (Silver Spring). 2013;21:E640-8 pubmed publisher
Roudkenar M, Halabian R, Roushandeh A, Nourani M, Masroori N, Ebrahimi M, et al. Lipocalin 2 regulation by thermal stresses: protective role of Lcn2/NGAL against cold and heat stresses. Exp Cell Res. 2009;315:3140-51 pubmed publisher
Pitashny M, Schwartz N, Qing X, Hojaili B, Aranow C, Mackay M, et al. Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. Arthritis Rheum. 2007;56:1894-903 pubmed

product information

brand :

R&D Systems

master code :

1757-LC

SKU :

1757-LC-050

product name :

Recombinant Human Lipocalin-2/NGAL Protein, CF

description :

The Recombinant Human Lipocalin-2/NGAL Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Lipocalin-2/NGAL Protein, CF has been validated for the following applications: Binding Activity.

target :

Lipocalin-2/NGAL

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Supplied as a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

25-27 kDa doublet, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

LCN2

details of functionality :

Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in Lipocalin-2. rhLipocalin-2 can bind 1.5 µM of Fe(DHBA)3 under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1757-LC

accessionNumbers :

P80188

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human Lipocalin-2/NGAL protein Gln21-Gly198, with a C-terminal 10-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, HNL, LCN2, lipocalin 2, lipocalin 2 (oncogene 24p3), Lipocalin2, Lipocalin-2, migration-stimulating factor inhibitor, MSFI, neutrophil gelatinase-associated lipocalin, NGAL, NGALlipocalin-2, Oncogene 24p3, p25, Siderocalin, Uterocalin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.