product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Lipocalin-2/NGAL Protein, CF
catalog :
1757-LC-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 24
Reference
Li P, Chen J, Wang M, Wang Q, Liu X. High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation. Mol Med Rep. 2024;30: pubmed publisher
Gupta U, Ghosh S, Wallace C, Shang P, Xin Y, Nair A, et al. Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD. Autophagy. 2023;19:92-111 pubmed publisher
Santus W, Rana A, Devlin J, Kiernan K, Jacob C, Tjokrosurjo J, et al. Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization. Nat Microbiol. 2022;7:2025-2038 pubmed publisher
Cook L, Sengelmann M, Winkler B, Nagl C, Koch S, Schlomann U, et al. ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9. Int J Mol Sci. 2022;23: pubmed publisher
Schr xf6 der S, Pino xe9 Schmidt M, Weiskirchen R. Lipocalin-2 (LCN2) Deficiency Leads to Cellular Changes in Highly Metastatic Human Prostate Cancer Cell Line PC-3. Cells. 2022;11: pubmed publisher
Zhang W, Pan R, Lu M, Zhang Q, Lin Z, Qin Y, et al. Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway. Oncogene. 2021;40:6369-6380 pubmed publisher
Wen X, Su B, Gao M, Chen J, Zhou D, You H, et al. Obesity-associated up-regulation of lipocalin 2 protects gastric mucosa cells from apoptotic cell death by reducing endoplasmic reticulum stress. Cell Death Dis. 2021;12:221 pubmed publisher
Tyagi A, Sharma S, Wu K, Wu S, Xing F, Liu Y, et al. Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun. 2021;12:474 pubmed publisher
Hui Z, Jiang Z, Qiao D, Bo Z, Qiyuan K, Shaohua B, et al. Increased expression of LCN2 formed a positive feedback loop with activation of the ERK pathway in human kidney cells during kidney stone formation. Sci Rep. 2020;10:21287 pubmed publisher
Yahiro K, Ogura K, Goto Y, Iyoda S, Kobayashi T, Takeuchi H, et al. Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival. Sci Rep. 2020;10:18943 pubmed publisher
Bauvois B, Pramil E, Jondreville L, Chapiro E, Quiney C, Maloum K, et al. Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia. Cancers (Basel). 2020;12: pubmed publisher
An S, Raju I, Surenkhuu B, Kwon J, Gulati S, Karaman M, et al. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019;: pubmed publisher
Zhao Y, Xia Q, Liu Y, Bai W, Yao Y, Ding J, et al. TCF7L2 and EGR1 synergistic activation of transcription of LCN2 via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma cells. Cell Signal. 2019;55:8-16 pubmed publisher
Parmar T, Parmar V, Perusek L, Georges A, Takahashi M, Crabb J, et al. Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration. J Immunol. 2018;200:3128-3141 pubmed publisher
Yan C, Yuanjie T, Zhengqun X, Jiayan C, Kongdan L. Neutrophil Gelatinase-Associated Lipocalin Attenuates Ischemia/Reperfusion Injury in an In Vitro Model via Autophagy Activation. Med Sci Monit. 2018;24:479-485 pubmed
Gomez Chou S, Swidnicka Siergiejko A, Badi N, Chavez Tomar M, Lesinski G, Bekaii Saab T, et al. Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment. Cancer Res. 2017;77:2647-2660 pubmed publisher
Wang B, Chen G, Li J, Zeng Y, Wu Y, Yan X. Neutrophil gelatinase-associated lipocalin predicts myocardial dysfunction and mortality in severe sepsis and septic shock. Int J Cardiol. 2017;227:589-594 pubmed publisher
Saha P, Yeoh B, Singh R, Chandrasekar B, Vemula P, Haribabu B, et al. Gut Microbiota Conversion of Dietary Ellagic Acid into Bioactive Phytoceutical Urolithin A Inhibits Heme Peroxidases. PLoS ONE. 2016;11:e0156811 pubmed publisher
Cantaluppi V, Dellepiane S, Tamagnone M, Medica D, Figliolini F, Messina M, et al. Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors. PLoS ONE. 2015;10:e0129279 pubmed publisher
Drew B, Hamidi H, Zhou Z, Villanueva C, Krum S, Calkin A, et al. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015;290:5566-81 pubmed publisher
La Manna G, Ghinatti G, Tazzari P, Alviano F, Ricci F, Capelli I, et al. Neutrophil gelatinase-associated lipocalin increases HLA-G(+)/FoxP3(+) T-regulatory cell population in an in vitro model of PBMC. PLoS ONE. 2014;9:e89497 pubmed publisher
Paton C, Rogowski M, Kozimor A, Stevenson J, Chang H, Cooper J. Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women. Obesity (Silver Spring). 2013;21:E640-8 pubmed publisher
Roudkenar M, Halabian R, Roushandeh A, Nourani M, Masroori N, Ebrahimi M, et al. Lipocalin 2 regulation by thermal stresses: protective role of Lcn2/NGAL against cold and heat stresses. Exp Cell Res. 2009;315:3140-51 pubmed publisher
Pitashny M, Schwartz N, Qing X, Hojaili B, Aranow C, Mackay M, et al. Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. Arthritis Rheum. 2007;56:1894-903 pubmed
product information
brand :
R&D Systems
master code :
1757-LC
SKU :
1757-LC-050
product name :
Recombinant Human Lipocalin-2/NGAL Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human Lipocalin-2/NGAL Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Lipocalin-2/NGAL Protein, CF has been validated for the following applications: Binding Activity.
target :
Lipocalin-2/NGAL
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
25-27 kDa doublet, reducing conditions
theoretical molecular weight :
22 kDa
gene symbol :
LCN2
details of functionality :
Measured by its ability to bind Iron(III) dihydroxybenzoic acid [Fe(DHBA)3]. The binding of Fe(DHBA)3 results in the quenching of Trp fluorescence in Lipocalin-2. rhLipocalin-2 can bind 1.5 ╡M of Fe(DHBA)3 under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P80188
applications :
Binding Activity
source :
NS0-derived Recombinant Human Lipocalin-2/NGAL Protein, CF
USD :
432 USD
alt names :
24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, HNL, LCN2, lipocalin 2, lipocalin 2 (oncogene 24p3), Lipocalin2, Lipocalin-2, migration-stimulating factor inhibitor, MSFI, neutrophil gelatinase-associated lipocalin, NGAL, NGALlipocalin-2, Oncogene 24p3, p25, Siderocalin, Uterocalin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.