Recombinant Human TrkA Fc Chimera Protein, CF | R&D Systems 175-TK product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TrkA Fc Chimera Protein, CF

catalog :

175-TK

quantity :

50 ug

price :

339 USD

citations: 8

Reference
Poole A, Frigotto L, Smith M, Baar C, Ivanova Berndt G, Jaulent A, et al. A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics. Sci Rep. 2019;9:930 pubmed publisher
Hall J, Gomez Pinilla F, Savage L. Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Front Neurosci. 2018;12:773 pubmed publisher
Hurtado Zavala J, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, et al. TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus. Nat Commun. 2017;8:15878 pubmed publisher
Sleigh J, Dawes J, West S, Wei N, Spaulding E, Gómez Martín A, et al. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations. Proc Natl Acad Sci U S A. 2017;114:E3324-E3333 pubmed publisher
Prencipe G, Minnone G, Strippoli R, De Pasquale L, Petrini S, Caiello I, et al. Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J Immunol. 2014;192:3345-54 pubmed publisher
Tsai C, Chan J, Hsu K, Chang A, Chan S. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS ONE. 2012;7:e33527 pubmed publisher
Vaegter C, Jansen P, Fjorback A, Glerup S, Skeldal S, Kjolby M, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci. 2011;14:54-61 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher

product information

brand :

R&D Systems

master code :

175-TK

SKU :

175-TK-050

product name :

Recombinant Human TrkA Fc Chimera Protein, CF

description :

The Recombinant Human TrkA Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TrkA Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

TrkA

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

115-125 kDa, reducing conditions

theoretical molecular weight :

67.4 kDa (monomer)

gene symbol :

NTRK1

details of functionality :

Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 0.8-4 µg/mL in the presence of 10 ng/mL of rhNGF.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

175-TK

accessionNumbers :

AAA36770

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human TrkA protein Human TrkA (Ala33-Glu407) Accession #AAA36770 IEGRID Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

DKFZp781I14186, EC 2.7.10, EC 2.7.10.1, MTChigh affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase, receptor, type 1, NTRK1, NTRK-1, p140-TrkA, TRK1-transforming tyrosine kinase protein, Trk-A, TRKAOncogene TRK, TRKTRK1, tyrosine kinase receptor A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.