product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Rat ROBO1 Fc Chimera Protein, CF
catalog :
1749-RB-050
quantity :
50 ug
price :
598 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Li Q, Huang L, Ding Y, Sherchan P, Peng W, Zhang J. Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1-srGAP1 pathway in a rat model of germinal matrix hemorrhage. J Neuroinflammation. 2023;20:249 pubmed publisher
Gonçalves A, Correia Pinto J, Nogueira Silva C. ROBO2 signaling in lung development regulates SOX2/SOX9 balance, branching morphogenesis and is dysregulated in nitrofen-induced congenital diaphragmatic hernia. Respir Res. 2020;21:302 pubmed publisher
Bhosle V, Mukherjee T, Huang Y, Patel S, Pang B, Liu G, et al. SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling. Nat Commun. 2020;11:4112 pubmed publisher
Yeh M, Gonda Y, Mommersteeg M, Barber M, Ypsilanti A, Hanashima C, et al. Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014;34:5717-31 pubmed publisher
Göhrig A, Detjen K, Hilfenhaus G, Körner J, Welzel M, Arsenic R, et al. Axon guidance factor SLIT2 inhibits neural invasion and metastasis in pancreatic cancer. Cancer Res. 2014;74:1529-40 pubmed publisher
Ricaño Cornejo I, Altick A, García Peña C, Nural H, Echevarria D, Miquelajauregui A, et al. Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain. J Neurosci Res. 2011;89:1531-41 pubmed publisher
Hernández Miranda L, Cariboni A, Faux C, Ruhrberg C, Cho J, Cloutier J, et al. Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci. 2011;31:6174-87 pubmed publisher
Brantley Sieders D, Dunaway C, Rao M, Short S, Hwang Y, Gao Y, et al. Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res. 2011;71:976-87 pubmed publisher
Dunaway C, Hwang Y, Lindsley C, Cook R, Wu J, Boothby M, et al. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol. 2011;31:404-16 pubmed publisher
Geutskens S, Hordijk P, van Hennik P. The chemorepellent Slit3 promotes monocyte migration. J Immunol. 2010;185:7691-8 pubmed publisher
product information
brand :
R&D Systems
master code :
1749-RB
SKU :
1749-RB-050
product name :
Recombinant Rat ROBO1 Fc Chimera Protein, CF
unit size :
50 ug
seo description :
The Recombinant Rat ROBO1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Rat ROBO1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
ROBO1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Rat
observed molecular weight :
110-115 kDa, reducing conditions
theoretical molecular weight :
86.2 kDa (monomer)
gene symbol :
Robo1
details of functionality :
Measured by its binding ability in a functional ELISA. Biotinylated recombinant mouse Slit-3 immobilized on a streptavidin-coated plate at 1 ╡g/mL can bind Recombinant Rat ROBO1 Fc Chimera with an apparent Kd 10 nM.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O55005
applications :
Binding Activity
source :
NS0-derived Recombinant Rat ROBO1 Fc Chimera Protein, CF
USD :
598 USD
alt names :
DUTT1, DUTT1Drosophila) homolog 1, H-Robo-1, MGC131599, MGC133277, roundabout, axon guidance receptor, homolog 1 (Drosophila)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.