Recombinant Human Trappin-2/Elafin Protein, CF | R&D Systems 1747-PI product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Trappin-2/Elafin Protein, CF

catalog :

1747-PI

quantity :

10 ug

price :

359 USD

citations: 5

Reference
Labidi Galy S, Clauss A, Ng V, Duraisamy S, Elias K, Piao H, et al. Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors. Oncogene. 2015;34:373-83 pubmed publisher
Drannik A, Nag K, Yao X, Henrick B, Sallenave J, Rosenthal K. Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C. PLoS ONE. 2012;7:e35866 pubmed publisher
Drannik A, Nag K, Yao X, Henrick B, Jain S, Ball T, et al. Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells. J Virol. 2012;86:4599-610 pubmed publisher
Wilkinson T, Dhaliwal K, Hamilton T, Lipka A, Farrell L, Davidson D, et al. Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment. Am J Pathol. 2009;174:1338-46 pubmed publisher
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed

product information

brand :

R&D Systems

master code :

1747-PI

SKU :

1747-PI-010

product name :

Recombinant Human Trappin-2/Elafin Protein, CF

description :

The Recombinant Human Trappin-2/Elafin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Trappin-2/Elafin Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Trappin-2/Elafin/Skalp

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

13 kDa and 16 kDa, reducing conditions

theoretical molecular weight :

11 kDa

gene symbol :

PI3

details of functionality :

Measured by its ability to inhibit neutrophil elastase cleavage of the fluorogenic peptide substrate, MeOSuc-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin (MeOSuc-AAPV-AMC). The IC50 value is 50 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1747-PI

accessionNumbers :

P19957

applications :

Inhibition Activity

source :

Mouse myeloma cell line, NS0-derived human Trappin-2/Elafin protein Ala23-Gln117, with a C-terminal 10-His tag

2020 USD :

359

2021 USD :

359 USD

alt names :

cementoin, Elafin, Elastase-specific inhibitor, ESI, ESIWAP four-disulfide core domain protein 14, Peptidase inhibitor 3, peptidase inhibitor 3, skin-derived, PI3, PI-3, pre-elafin, protease inhibitor 3, skin-derived (SKALP), Protease inhibitor WAP3, SKALP, SKALPELAFIN, Skin-derived antileukoproteinase, trappin-2, Trappin2, WAP four-disulfide core domain 14, WAP3MGC13613, WFDC14elafin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.