Recombinant Human Trappin-2/Elafin Protein, CF | R&D Systems 1747-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Trappin-2/Elafin Protein, CF

catalog :

1747-PI-010

quantity :

10 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Cassuto J, Folestad A, Göthlin J, Malchau H, Kärrholm J. Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants. Bone Rep. 2020;13:100715 pubmed publisher
Labidi Galy S, Clauss A, Ng V, Duraisamy S, Elias K, Piao H, et al. Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors. Oncogene. 2015;34:373-83 pubmed publisher
Drannik A, Nag K, Yao X, Henrick B, Sallenave J, Rosenthal K. Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C. PLoS ONE. 2012;7:e35866 pubmed publisher
Drannik A, Nag K, Yao X, Henrick B, Jain S, Ball T, et al. Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells. J Virol. 2012;86:4599-610 pubmed publisher
Wilkinson T, Dhaliwal K, Hamilton T, Lipka A, Farrell L, Davidson D, et al. Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment. Am J Pathol. 2009;174:1338-46 pubmed publisher
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed

product information

brand :

R&D Systems

master code :

1747-PI

SKU :

1747-PI-010

product name :

Recombinant Human Trappin-2/Elafin Protein, CF

unit size :

10 ug

seo description :

The Recombinant Human Trappin-2/Elafin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Trappin-2/Elafin Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Trappin-2/Elafin

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

dilution :

Inhibition Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

13 kDa and 16 kDa, reducing conditions

theoretical molecular weight :

11 kDa

gene symbol :

PI3

details of functionality :

Measured by its ability to inhibit neutrophil elastase cleavage of the fluorogenic peptide substrate, MeOSuc-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin (MeOSuc-AAPV-AMC). The IC50 value is 50 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P19957

applications :

Inhibition Activity

source :

NS0-derived Recombinant Human Trappin-2/Elafin Protein, CF

USD :

456 USD

alt names :

cementoin, Elafin, Elastase-specific inhibitor, ESI, ESIWAP four-disulfide core domain protein 14, Peptidase inhibitor 3, peptidase inhibitor 3, skin-derived, PI3, PI-3, pre-elafin, protease inhibitor 3, skin-derived (SKALP), Protease inhibitor WAP3, SKALP, SKALPELAFIN, Skin-derived antileukoproteinase, trappin-2, Trappin2, WAP four-disulfide core domain 14, WAP3MGC13613, WFDC14elafin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage