This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TREM2 Fc Chimera Protein, CF
catalog :
1729-T2
quantity :
50 ug
price :
339 USD
citations: 4
Reference
Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim J, Hsieh C, et al. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015;35:3384-96 pubmed publisher
Chertoff M, Shrivastava K, Gonzalez B, Acarin L, Gimenez Llort L. Differential modulation of TREM2 protein during postnatal brain development in mice. PLoS ONE. 2013;8:e72083 pubmed publisher
Hsieh C, Koike M, Spusta S, Niemi E, Yenari M, Nakamura M, et al. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009;109:1144-56 pubmed publisher
Hamerman J, Jarjoura J, Humphrey M, Nakamura M, Seaman W, Lanier L. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006;177:2051-5 pubmed
product information
brand :
R&D Systems
master code :
1729-T2
SKU :
1729-T2-050
product name :
Recombinant Mouse TREM2 Fc Chimera Protein, CF
description :
The Recombinant Mouse TREM2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TREM2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
TREM2b
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
60-70 kDa, reducing conditions
theoretical molecular weight :
43 kDa (monomer)
gene symbol :
Trem2
details of functionality :
Measured by its ability to bind fluorescein-conjugated S. aureus Bioparticles. Daws, M.R. et al . (2003) J. Immunol. 171 :594. The ED50 for this effect is 0.3-1.5 µg/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
1729-T2
accessionNumbers :
Q99NH8
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived mouse TREM-2 protein Mouse TREM-2 (Leu19-Pro168) Accession # Q99NH8 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
2020 USD :
339
2021 USD :
339 USD
alt names :
PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.