Recombinant Mouse TREM2 Fc Chimera Protein, CF | R&D Systems 1729-T2-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TREM2 Fc Chimera Protein, CF

catalog :

1729-T2-050

quantity :

50 ug

price :

432 USD

citations: 9

Reference
Pierro E, Cottam M, An H, Lehmann B, Pietenpol J, Wellen K, et al. Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations. bioRxiv. 2024;: pubmed publisher
Chen J, Zhu T, Jiang G, Zeng Q, Li Z, Huang X. Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer. Mol Cancer. 2023;22:131 pubmed publisher
Yin T, D ADAMIO L. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv. 2023;: pubmed publisher
You S, Brase L, Filipello F, Iyer A, Del Aguila J, He J, et al. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv. 2023;: pubmed publisher
Dong Y, D Mello C, Pinsky W, Lozinski B, Kaushik D, Ghorbani S, et al. Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia. Nat Neurosci. 2021;24:489-503 pubmed publisher
Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim J, Hsieh C, et al. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015;35:3384-96 pubmed publisher
Chertoff M, Shrivastava K, Gonzalez B, Acarin L, Gimenez Llort L. Differential modulation of TREM2 protein during postnatal brain development in mice. PLoS ONE. 2013;8:e72083 pubmed publisher
Hsieh C, Koike M, Spusta S, Niemi E, Yenari M, Nakamura M, et al. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009;109:1144-56 pubmed publisher
Hamerman J, Jarjoura J, Humphrey M, Nakamura M, Seaman W, Lanier L. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006;177:2051-5 pubmed

product information

master code :

1729-T2

SKU :

1729-T2-050

product name :

Recombinant Mouse TREM2 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse TREM2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse TREM2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

TREM2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

60-70 kDa, reducing conditions

theoretical molecular weight :

43 kDa (monomer)

gene symbol :

Trem2

details of functionality :

Measured by its ability to bind fluorescein-conjugated S. aureus Bioparticles. Daws, M.R. et al . (2003) J. Immunol. 171 :594. The ED50 for this effect is 0.3-1.5 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q99NH8

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse TREM-2 protein Mouse TREM-2 (Leu19-Pro168) Accession # Q99NH8 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.