product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Jagged 2 Fc Chimera Protein, CF
catalog :
1726-JG-050
quantity :
50 ug
price :
498 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
Alve S, Gramolelli S, Jukonen J, Juteau S, Pink A, Manninen A, et al. DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells. JCI Insight. 2024;9: pubmed publisher
Li Q, Zhang J, Ma L, Wu C, Zhao J, Guan W, et al. ILC2s induce adaptive Th2-type immunity in different stages of tuberculosis through the Notch-GATA3 pathway. Int Immunopharmacol. 2021;101:108330 pubmed publisher
Palano M, Giannandrea D, Platonova N, Gaudenzi G, Falleni M, Tosi D, et al. Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells. Cancers (Basel). 2020;12: pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Yang M, Zhang G, Wang Y, He M, Xu Q, Lu J, et al. Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer. Br J Cancer. 2020;123:1404-1416 pubmed publisher
Zhang D, Qiao X, Wang L, Zhang L, Yao J, Wu X, et al. Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations. Cell Signal. 2020;68:109537 pubmed publisher
Lopez Guerra M, Xargay Torrent S, Fuentes P, Roldán J, González Farre B, Rosich L, et al. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells. Oncogene. 2020;39:1185-1197 pubmed publisher
Colombo M, Garavelli S, Mazzola M, Platonova N, Giannandrea D, Colella R, et al. Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance. Haematologica. 2020;105:1925-1936 pubmed publisher
Kannan S, Aitken M, Herbrich S, Golfman L, Hall M, Mak D, et al. Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019;: pubmed publisher
Wu X, Yao J, Wang L, Zhang D, Zhang L, Reynolds E, et al. Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells. Cells. 2019;8: pubmed publisher
Schwentner R, Jug G, Kauer M, Schnöller T, Waidhofer Söllner P, Holter W, et al. JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis-like cells. J Leukoc Biol. 2019;105:101-111 pubmed publisher
Diaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge S. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol. 2013;201:279-92 pubmed publisher
Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher
Erceg S, Lukovic D, Moreno Manzano V, Stojkovic M, Bhattacharya S. Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2012;Chapter 1:Unit 1H.5 pubmed publisher
product information
brand :
R&D Systems
master code :
1726-JG
SKU :
1726-JG-050
product name :
Recombinant Human Jagged 2 Fc Chimera Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human Jagged 2 Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Jagged 2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Jagged 2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and EDTA.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
165-175 kDa, reducing conditions
theoretical molecular weight :
138.7 kDa (monomer)
gene symbol :
JAG2
details of functionality :
Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.5-2 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
AAB84215
applications :
Bioactivity
source :
CHO-derived Recombinant Human Jagged 2 Fc Chimera Protein, CF
USD :
498 USD
alt names :
HJ2, JAG2, jagged 2, Jagged2, protein jagged-2, SER2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.