Nolfi Donegan D, Annarapu G, St Croix C, Calderon M, Hillery C, Shiva S. High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease. JCI Insight. 2024;9: pubmed publisher

Tsoporis J, Triantafyllis A, Kalogeropoulos A, Izhar S, Rigopoulos A, Rallidis L, et al. Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia. Biomolecules. 2023;14: pubmed publisher

Roux A, Yuan H, Podshivalova K, HENDRICKSON D, Kerr R, Kenyon C, et al. Individual cell types in C. elegans age differently and activate distinct cell-protective responses. Cell Rep. 2023;42:112902 pubmed publisher

Pujals M, Mayans C, Bellio C, M xe9 ndez O, Greco E, Fasani R, et al. RAGE/SNAIL1 signaling drives epithelial-mesenchymal plasticity in metastatic triple-negative breast cancer. Oncogene. 2023;42:2610-2628 pubmed publisher

Overstreet A, Anderson B, Burge M, Zhu X, Tao Y, Cham C, et al. HMGB1 acts as an agent of host defense at the gut mucosal barrier. bioRxiv. 2023;: pubmed publisher

Xu K, Wang M, Wang H, Zhao S, Tu D, Gong X, et al. HMGB1/STAT3/p65 axis drives microglial activation and autophagy exert a crucial role in chronic Stress-Induced major depressive disorder. J Adv Res. 2023;: pubmed publisher

Zhang Q, Chen Y, Wang Q, Wang Y, Feng W, Chai L, et al. HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo. Respir Res. 2023;24:149 pubmed publisher

Banks W, Hansen K, Erickson M, Crews F. High-mobility group box 1 (HMGB1) crosses the BBB bidirectionally. Brain Behav Immun. 2023;111:386-394 pubmed publisher

Kim S, Jung D, Song J, Jung J, Jung J, Lee H, et al. Targeting IKKβ Activity to Limit Sterile Inflammation in Acetaminophen-Induced Hepatotoxicity in Mice. Pharmaceutics. 2023;15: pubmed publisher

Zheng J, Lan P, Li M, Kang M, Xun M, Ma X, et al. Anti-Na+/K+-ATPase DR antibody attenuates UUO-induced renal fibrosis through inhibition of Na+/K+-ATPase α1-dependent HMGB1 release. Int Immunopharmacol. 2023;116:109826 pubmed publisher

Osonoi S, Mizukami H, Takeuchi Y, Sugawa H, Ogasawara S, Takaku S, et al. RAGE activation in macrophages and development of experimental diabetic polyneuropathy. JCI Insight. 2022;7: pubmed publisher

Takasawa S, Tsuchida C, Sakuramoto Tsuchida S, Uchiyama T, Makino M, Yamauchi A, et al. Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24. J Cell Mol Med. 2022;26:4710-4720 pubmed publisher

Roth C, Craveiro R, Niederau C, Malyaran H, Neuss S, Jankowski J, et al. Mechanical Compression by Simulating Orthodontic Tooth Movement in an In Vitro Model Modulates Phosphorylation of AKT and MAPKs via TLR4 in Human Periodontal Ligament Cells. Int J Mol Sci. 2022;23: pubmed publisher

Amornsupak K, Thongchot S, Thinyakul C, Box C, Hedayat S, Thuwajit P, et al. HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells. BMC Cancer. 2022;22:578 pubmed publisher

Bi X, Yan X, Jiang B, Liang J, Zhou J, Lu S, et al. Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses. Toxicol Appl Pharmacol. 2021;433:115778 pubmed publisher

Fischer S, Nasyrov E, Brosien M, Preissner K, Marti H, Kunze R. Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals. J Neuroinflammation. 2021;18:252 pubmed publisher

Liu L, Liu S, Luo H, Chen C, Zhang X, He L, et al. GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cells. Aging (Albany NY). 2021;13:16178-16197 pubmed publisher

Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara Tani R, Sasaki T, et al. Role of Glycated High Mobility Group Box-1 in Gastric Cancer. Int J Mol Sci. 2021;22: pubmed publisher

Monir A, Mukaibo T, Abd El Aal A, Nodai T, Munemasa T, Kondo Y, et al. Local administration of HMGB-1 promotes bone regeneration on the critical-sized mandibular defects in rabbits. Sci Rep. 2021;11:8950 pubmed publisher

Chen M, Zhu L, Xue M, Zhu R, Jing L, Wang H, et al. HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin. Sci Rep. 2021;11:5059 pubmed publisher

Chen R, Huang Y, Quan J, Liu J, Wang H, Billiar T, et al. HMGB1 as a potential biomarker and therapeutic target for severe COVID-19. Heliyon. 2020;6:e05672 pubmed publisher

Weber B, Lackner I, Baur M, Fois G, Gebhard F, Marzi I, et al. Effects of Circulating HMGB-1 and Histones on Cardiomyocytes-Hemadsorption of These DAMPs as Therapeutic Strategy after Multiple Trauma. J Clin Med. 2020;9: pubmed publisher

Wang P, Chen F, Zhang X. Cyclosporine-a attenuates retinal inflammation by inhibiting HMGB-1 formation in rats with type 2 diabetes mellitus. BMC Pharmacol Toxicol. 2020;21:9 pubmed publisher

Wang Z, Zhou H, Zheng H, Zhou X, Shen G, Teng X, et al. Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation. Autophagy. 2021;17:529-552 pubmed publisher

Le Y, Wang Y, Zhou L, Xiong J, Tian J, Yang X, et al. Cigarette smoke-induced HMGB1 translocation and release contribute to migration and NF-κB activation through inducing autophagy in lung macrophages. J Cell Mol Med. 2020;24:1319-1331 pubmed publisher

Liu F, Fan D, Yang Z, Tang N, Guo Z, Ma S, et al. TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis. Cell Death Dis. 2019;10:480 pubmed publisher

Kim S, Ryu M, Han J, Jang Y, Lee M, Ju X, et al. Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced Parkinsonian mouse model. Lab Invest. 2019;: pubmed publisher

Hwang J, Chu H, Ahn Y, Kim J, Kim D. HMGB1 promotes hair growth via the modulation of prostaglandin metabolism. Sci Rep. 2019;9:6660 pubmed publisher

Nicaise A, Wagstaff L, Willis C, Paisie C, Chandok H, Robson P, et al. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. Proc Natl Acad Sci U S A. 2019;116:9030-9039 pubmed publisher

Yang W, Kim J, Lee M, Lee E, Park S. Ectodomain Shedding of RAGE and TLR4 as a Negative Feedback Regulation in High-Mobility Group Box 1-Activated Aortic Endothelial Cells. Cell Physiol Biochem. 2018;51:1632-1644 pubmed publisher

Mou K, Liu W, Miao Y, Cao F, Li P. HMGB1 deficiency reduces H2 O2 -induced oxidative damage in human melanocytes via the Nrf2 pathway. J Cell Mol Med. 2018;22:6148-6156 pubmed publisher

Rayavara K, Kurosky A, Stafford S, Garg N, Brasier A, Garofalo R, et al. Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation. J Immunol. 2018;201:2753-2766 pubmed publisher

Wu H, Chen Z, Chen J, Pei L, Xie J, Wei Z, et al. High Mobility Group B-1 (HMGB-1) Promotes Apoptosis of Macrophage-Derived Foam Cells by Inducing Endoplasmic Reticulum Stress. Cell Physiol Biochem. 2018;48:1019-1029 pubmed publisher

Bestall S, Hulse R, Blackley Z, Swift M, Ved N, Paton K, et al. Sensory neuronal sensitisation occurs through HMGB-1-RAGE and TRPV1 in high-glucose conditions. J Cell Sci. 2018;131: pubmed publisher

Senthilkumar D, Rajukumar K, Kumar M, Kalaiyarasu S, Shrivastava D, Katare M, et al. Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in experimentally infected piglets. Cytokine. 2019;113:21-30 pubmed publisher

Kim S, Son M, Lee S, Park I, Kwak M, Han M, et al. High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation. Front Immunol. 2018;9:705 pubmed publisher

Mori H, Murakami M, Tsuda T, Kameda K, Utsunomiya R, Masuda K, et al. Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes. J Dermatol Sci. 2018;90:154-165 pubmed publisher

Dyer M, Chen Q, Haldeman S, Yazdani H, Hoffman R, Loughran P, et al. Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA. Sci Rep. 2018;8:2068 pubmed publisher

Gruda M, Ruggeberg K, O Sullivan P, Guliashvili T, Scheirer A, Golobish T, et al. Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads. PLoS ONE. 2018;13:e0191676 pubmed publisher

Abu El Asrar A, Alam K, García Ramírez M, Ahmad A, Siddiquei M, Mohammad G, et al. Association of HMGB1 with oxidative stress markers and regulators in PDR. Mol Vis. 2017;23:853-871 pubmed

Park S, Kwak J, Jung S, Ahn B, Cho W, Yun C, et al. Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity. Exp Mol Med. 2017;49:e392 pubmed publisher

Zhang F, Su X, Huang G, Xin X, Cao E, Shi Y, et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells. Sci Rep. 2017;7:14268 pubmed publisher

Zhu J, Wang F, Wang H, Dong N, Zhu X, Wu Y, et al. TNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein. Sci Rep. 2017;7:12239 pubmed publisher

Ding L, Buckwalter J, Martin J. DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm. 2017;2017:2642549 pubmed publisher

Deng H, Wang C, Chang D, Hu N, Chen M, Zhao M. High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route. Arthritis Res Ther. 2017;19:125 pubmed publisher

Taylor O, Thatcher M, Carr S, Gibbs J, Trumbull A, Harrison M, et al. High-Mobility Group Box 1 Disrupts Metabolic Function with Cigarette Smoke Exposure in a Ceramide-Dependent Manner. Int J Mol Sci. 2017;18: pubmed publisher

Li Z, Fan E, Liu J, Scott M, Li Y, Li S, et al. Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma. Cell Death Dis. 2017;8:e2775 pubmed publisher

Zhao F, Fang Y, Deng S, Li X, Zhou Y, Gong Y, et al. Glycyrrhizin Protects Rats from Sepsis by Blocking HMGB1 Signaling. Biomed Res Int. 2017;2017:9719647 pubmed publisher

Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi M, et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol. 2017;140:584-587.e8 pubmed publisher

Wang C, Chang D, Chen M, Zhao M. HMGB1 contributes to glomerular endothelial cell injury in ANCA-associated vasculitis through enhancing endothelium-neutrophil interactions. J Cell Mol Med. 2017;21:1351-1360 pubmed publisher

Yeap W, Wong K, Shimasaki N, Teo E, Quek J, Yong H, et al. CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. Sci Rep. 2016;6:34310 pubmed publisher

Wang J, Han D, Sun M, Feng J. Cerebral ischemic post?conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model. Mol Med Rep. 2016;14:4162-4172 pubmed publisher

Yang J, Zhao Y, Zhang P, Li Y, Yang Y, Yang Y, et al. Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS. Cell Death Dis. 2016;7:e2363 pubmed publisher

Shang D, Peng T, Gou S, Li Y, Wu H, Wang C, et al. High Mobility Group Box Protein 1 Boosts Endothelial Albumin Transcytosis through the RAGE/Src/Caveolin-1 Pathway. Sci Rep. 2016;6:32180 pubmed publisher

Tago K, Inoue K, Ouchi M, Miura Y, Kubota K. Receptor for advanced glycation endproducts signaling cascades are activated in pancreatic fibroblasts, but not in the INS1E insulinoma cell line: Are mesenchymal cells major players in chronic inflammation?. Islets. 2016;8:135-44 pubmed publisher

Chen Q, Bei J, Liu C, Feng S, Zhao W, Zhou Z, et al. HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization. PLoS ONE. 2016;11:e0156686 pubmed publisher

Dyer K, Rosenberg H. Physiologic concentrations of HMGB1 have no impact on cytokine-mediated eosinophil survival or chemotaxis in response to Eotaxin-2 (CCL24). PLoS ONE. 2015;10:e0118887 pubmed publisher

Lee C, Wang C, Lee Y, Tsai Y, Liu J. High mobility group box 1 induced human lung myofibroblasts differentiation and enhanced migration by activation of MMP-9. PLoS ONE. 2015;10:e0116393 pubmed publisher

Vogel S, Börger V, Peters C, Förster M, Liebfried P, Metzger K, et al. Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death. Cell Death Differ. 2015;22:1219-30 pubmed publisher

Park S, Lee S, Kim H, Lee W, Hong K, Kim C. HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation. Eur J Immunol. 2015;45:1216-27 pubmed publisher

Yang P, Kim D, Lee Y, Lee S, Kang W, Chang H, et al. Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats. Respir Res. 2014;15:148 pubmed publisher

Kim H, Park S, Lee S, Lee H, Lee W, Rhim B, et al. Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis. PLoS ONE. 2014;9:e104743 pubmed publisher

Zhou H, Ji X, Wu Y, Xuan J, Qi Z, Shen L, et al. A dual-role of Gu-4 in suppressing HMGB1 secretion and blocking HMGB1 pro-inflammatory activity during inflammation. PLoS ONE. 2014;9:e89634 pubmed publisher

Thierry A, Giraud S, Robin A, Barra A, Bridoux F, Ameteau V, et al. The alarmin concept applied to human renal transplantation: evidence for a differential implication of HMGB1 and IL-33. PLoS ONE. 2014;9:e88742 pubmed publisher

Vogel S, Chatterjee M, Metzger K, Borst O, Geisler T, Seizer P, et al. Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET. J Biol Chem. 2014;289:11068-82 pubmed publisher

Santos A, Dvoriantchikova G, Li Y, Mohammad G, Abu El Asrar A, Wen R, et al. Cellular mechanisms of high mobility group 1 (HMGB-1) protein action in the diabetic retinopathy. PLoS ONE. 2014;9:e87574 pubmed publisher

Luo Y, Yoneda J, Ohmori H, Sasaki T, Shimbo K, Eto S, et al. Cancer usurps skeletal muscle as an energy repository. Cancer Res. 2014;74:330-40 pubmed publisher

Suwara M, Green N, Borthwick L, Mann J, Mayer Barber K, Barron L, et al. IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol. 2014;7:684-93 pubmed publisher

Chen J, Matzuk M, Zhou X, Lu C. Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury. Kidney Int. 2012;82:1195-207 pubmed publisher

Feldman P, Due M, Ripsch M, Khanna R, White F. The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain. J Neuroinflammation. 2012;9:180 pubmed publisher

Arumugam T, Ramachandran V, Gomez S, Schmidt A, Logsdon C. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012;18:4356-64 pubmed publisher

Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS ONE. 2011;6:e23132 pubmed publisher

Ley C, Svala E, Nilton A, Lindahl A, Eloranta M, Ekman S, et al. Effects of high mobility group box protein-1, interleukin-1?, and interleukin-6 on cartilage matrix metabolism in three-dimensional equine chondrocyte cultures. Connect Tissue Res. 2011;52:290-300 pubmed publisher

Ruan B, Li X, Winkler A, Cunningham K, Kuai J, Greco R, et al. Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-? production in a receptor for advanced glycation end product-dependent manner. J Immunol. 2010;185:4213-22 pubmed publisher

Rao N, Argyle B, Xu X, Reynolds P, Walenga J, Prechel M, et al. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol. 2010;299:C97-110 pubmed publisher

Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Jiang Y, et al. Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1670-80 pubmed publisher

Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 2009;15:1170-8 pubmed publisher

Zhou J, Huang J, Poon V, Chen D, Chan C, Ng F, et al. Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. J Hepatol. 2009;51:322-32 pubmed publisher

Tzeng H, Fan J, Vallejo J, Dong J, Chen X, Houser S, et al. Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H1490-6 pubmed publisher

Kiryushko D, Novitskaya V, Soroka V, Klingelhofer J, Lukanidin E, Berezin V, et al. Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol. 2006;26:3625-38 pubmed