Recombinant Human ICOS Fc Chimera Protein, CF | R&D Systems 169-CS-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ICOS Fc Chimera Protein, CF

catalog :

169-CS-050

quantity :

50 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
McKinski K, McNulty D, Zappacosta F, Birchler M, Szapacs M, Evans C. Orthogonal quantification of soluble inducible T-cell costimulator (ICOS) in healthy and diseased human serum. J Pharm Anal. 2022;12:317-323 pubmed publisher
Koh K, Cao Y, Mangos S, Tardi N, Dande R, Lee H, et al. Nonimmune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist. J Clin Invest. 2019;129:1713-1726 pubmed publisher
Mesturini R, Nicola S, Chiocchetti A, Bernardone I, Castelli L, Bensi T, et al. ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cells. Eur J Immunol. 2006;36:2601-12 pubmed

product information

brand :

R&D Systems

master code :

169-CS

SKU :

169-CS-050

product name :

Recombinant Human ICOS Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human ICOS Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ICOS Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ICOS

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

50-60 kDa, reducing conditions

theoretical molecular weight :

40.3 kDa (monomer)

gene symbol :

ICOS

details of functionality :

Measured by its ability to inhibit human T cell proliferation induced by rhB7-H2/Fc Chimera in the presence of anti-CD3. Wang, S. et al . (2000) Blood 96 :2808. The ED50 for this effect is 1-4 ╡g/mL in the presence of 3 ╡g/mL Recombinant Human B7-H2 Fc Chimera (Catalog # 165-B7 ) and at least 20 ng/mL of anti-CD3. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human ICOS Fc Chimera Protein Bioactivity

accessionNumbers :

Q9Y6W8

applications :

Bioactivity

source :

NS0-derived Recombinant Human ICOS Fc Chimera Protein, CF

USD :

400 USD

alt names :

Activation-inducible lymphocyte immunomediatory molecule, AILIM, AILIMCD278, CD278, CD278 antigen, CRP-1, CVID1, inducible costimulator, inducible T-cell costimulator, inducible T-cell co-stimulator, MGC39850

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage