Recombinant Human PDGF-CC Protein | R&D Systems 1687-CC-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PDGF-CC Protein

catalog :

1687-CC-025

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 13

Reference
Akiyama T, Yasuda T, Uchihara T, Yasuda Yoshihara N, Tan B, Yonemura A, et al. Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors. Cancer Res. 2023;83:753-770 pubmed publisher
Li Q, Ming Y, Jia H, Wang G. Poricoic acid A suppresses TGF-β1-induced renal fibrosis and proliferation via the PDGF-C, Smad3 and MAPK pathways. Exp Ther Med. 2021;21:289 pubmed publisher
Yamamoto Y, Mukai A, Ikushima T, Urata Y, Kinoshita S, Hamuro J, et al. Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model. Sci Rep. 2020;10:20936 pubmed publisher
López Bellido R, Puig S, Huang P, Tsai C, Turner H, Galko M, et al. Growth factor signaling regulates mechanical nociception in flies and vertebrates. J Neurosci. 2019;: pubmed publisher
Mahjour F, Dambal V, Shrestha N, Singh V, Noonan V, Kantarci A, et al. Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB. Oncogenesis. 2019;8:34 pubmed publisher
Mamer S, Chen S, Weddell J, Palasz A, Wittenkeller A, Kumar M, et al. Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics. Sci Rep. 2017;7:16439 pubmed publisher
He H, Kuriyan A, Su C, Mahabole M, Zhang Y, Zhu Y, et al. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3. Sci Rep. 2017;7:43736 pubmed publisher
Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, et al. Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat. Nat Commun. 2016;7:12152 pubmed publisher
Hayes B, Riehle K, Shimizu Albergine M, Bauer R, Hudkins K, Johansson F, et al. Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. PLoS ONE. 2014;9:e92925 pubmed publisher
Son D, Na Y, Hwang E, Seok S. Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation. J Biol Chem. 2014;289:6225-35 pubmed publisher
Ball S, Bayley C, Shuttleworth C, Kielty C. Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells. Biochem J. 2010;427:29-40 pubmed publisher
Crawford Y, Kasman I, Yu L, ZHONG C, Wu X, Modrusan Z, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell. 2009;15:21-34 pubmed publisher
Wågsäter D, Zhu C, Björck H, Eriksson P. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis. 2009;202:415-23 pubmed publisher

product information

brand :

R&D Systems

master code :

1687-CC

SKU :

1687-CC-025

product name :

Recombinant Human PDGF-CC Protein

unit size :

25 ug

seo description :

The Recombinant Human PDGF-CC Protein from R&D Systems is derived from E. coli. The Recombinant Human PDGF-CC Protein has been validated for the following applications: Bioactivity.

target :

PDGF-CC

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

13.4 kDa (monomer)

gene symbol :

PDGFC

details of functionality :

Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 70-350 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_057289

applications :

Bioactivity

source :

E. coli-derived Recombinant Human PDGF-CC Protein

USD :

400 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage