Recombinant Mouse IL-23R Fc Chimera Protein, CF | R&D Systems 1686-MR-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-23R Fc Chimera Protein, CF

catalog :

1686-MR-050

quantity :

50 ug

price :

432 USD

citations: 4

Reference
Georgy J, Arlt Y, Moll J, Ouzin M, Weitz H, Gremer L, et al. Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction. J Biol Chem. 2021;297:101295 pubmed publisher
Roberts K, Cubitt M, Carlton T, Rodrigues Duarte L, Maggiore L, Chai R, et al. Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease. Sci Rep. 2021;11:19422 pubmed publisher
Uto Konomi A, Miyauchi K, Ozaki N, Motomura Y, Suzuki Y, Yoshimura A, et al. Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines. PLoS ONE. 2012;7:e40343 pubmed publisher
Oniki S, Nagai H, Horikawa T, Furukawa J, Belladonna M, Yoshimoto T, et al. Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma. Cancer Res. 2006;66:6395-404 pubmed

product information

master code :

1686-MR

SKU :

1686-MR-050

product name :

Recombinant Mouse IL-23R Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse IL-23R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-23R Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

IL-23R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

105 kDa, reducing conditions

theoretical molecular weight :

66.8 kDa (monomer)

gene symbol :

Il23r

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-23 R/Fc Chimera is immobilized at 5 ╡g/mL (100 ╡L/well) the concentration of Recombinant Mouse IL-23 (Catalog # 1887-ML ) that produces 50% of optimal binding response is approximately 5-25 ng/mL

endotoxin note :

<0.1 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q8K4B4

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived mouse IL-23 R protein Mouse IL-23 R (Gly24-Asp372) Accession # Q8K4B4 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

IBD17, IL-23 R, IL-23 receptor, IL23R, IL-23R, interleukin 23 receptor, interleukin-23 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.