Recombinant Human B7-H2 Fc Chimera Protein, CF | R&D Systems 165-B7-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human B7-H2 Fc Chimera Protein, CF

catalog :

165-B7-100

quantity :

100 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Locci M, Wu J, Arumemi F, Mikulski Z, Dahlberg C, Miller A, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976-84 pubmed publisher
Arcangeli M, Bardin F, Frontera V, Bidaut G, Obrados E, Adams R, et al. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. Stem Cells. 2014;32:1043-54 pubmed publisher
Weissmüller S, Semmler L, Kalinke U, Christians S, Muller Berghaus J, Waibler Z. ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation. Blood. 2012;119:6268-77 pubmed publisher
Mesturini R, Nicola S, Chiocchetti A, Bernardone I, Castelli L, Bensi T, et al. ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naïve CD4+ T cells. Eur J Immunol. 2006;36:2601-12 pubmed

product information

brand :

R&D Systems

master code :

165-B7

SKU :

165-B7-100

product name :

Recombinant Human B7-H2 Fc Chimera Protein, CF

unit size :

100 ug

seo description :

The Recombinant Human B7-H2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human B7-H2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

B7-H2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

80-90 kDa, reducing conditions

theoretical molecular weight :

53.4 kDa (monomer)

gene symbol :

ICOSLG

details of functionality :

Measured by its ability to stimulate human T cell proliferation in the presence of anti-CD3. Wang, S. et al . (2000) Blood 96 :2808. The ED50 for this effect is 0.3-1.2 ╡g/mL in the presence of anti-CD3 immobilized at least at 20 ng/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human B7-H2 Fc Chimera Protein Bioactivity

accessionNumbers :

O75144.2

applications :

Bioactivity

source :

NS0-derived Recombinant Human B7-H2 Fc Chimera Protein, CF

USD :

400 USD

alt names :

B7H2, B7H2B7 homolog 2, B7-H2B7-related protein 1, B7RP-1, B7RP1B7-like protein Gl50, B7RP-1LICOS, CD275, CD275 antigen, GL50, GL50transmembrane protein B7-H2 ICOS ligand, ICOSL, ICOS-L, ICOSLG, inducible T-cell co-stimulator ligand, KIAA0653ICOS ligand

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage