This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human NOV/CCN3 Protein, CF
catalog :
1640-NV
quantity :
50 ug
price :
329 USD
citations: 5
Reference
Kolb A, Shupp A, Mukhopadhyay D, Marini F, Bussard K. Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment. Breast Cancer Res. 2019;21:31 pubmed publisher
van Roeyen C, Boor P, Borkham Kamphorst E, Rong S, Kunter U, Martin I, et al. A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects. Am J Pathol. 2012;180:1979-90 pubmed publisher
Zhang Y, Wang C. Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells. Oncogene. 2011;30:3549-62 pubmed publisher
Sin W, Tse M, Planque N, Perbal B, Lampe P, Naus C. Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization. J Biol Chem. 2009;284:29935-44 pubmed publisher
Riser B, Najmabadi F, Perbal B, Peterson D, Rambow J, Riser M, et al. CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease. Am J Pathol. 2009;174:1725-34 pubmed publisher
product information
brand :
R&D Systems
master code :
1640-NV
SKU :
1640-NV-050
product name :
Recombinant Human NOV/CCN3 Protein, CF
description :
The Recombinant Human NOV/CCN3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human NOV/CCN3 Protein, CF has been validated for the following applications: Bioactivity.
target :
NOV/CCN3
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
55 kDa, reducing conditions
theoretical molecular weight :
37.1 kDa
gene symbol :
NOV
details of functionality :
Measured by its ability to mediate Balb/3T3 mouse embryonic fibroblast cell adhesion. Ball, D.K. et al . (2003) Reproduction 125 :271. rhNOV, immobilized at 10 µg/mL, 100 µL/well, will mediate 30% Balbc/3T3 cell adhesion (3 x 104 cells/well added).
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
1640-NV
accessionNumbers :
P48745
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human NOV/CCN3 protein Thr32-Met357, with a C-terminal 10-His tag
2020 USD :
329
2021 USD :
329 USD
alt names :
CCN family member 3, CCN3, CCN3IGF-binding protein 9, IBP-9, IGFBP-9, IGFBP9novH, Insulin-like growth factor-binding protein 9, nephroblastoma overexpressed gene, Nephroblastoma-overexpressed gene protein homolog, NOVH, protein NOV homolog
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.