product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Thrombospondin-2 Protein, CF
catalog :
1635-T2-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Corbella E, Fara C, Covarelli F, Porreca V, Palmisano B, Mignogna G, et al. THBS1 and THBS2 Enhance the In Vitro Proliferation, Adhesion, Migration and Invasion of Intrahepatic Cholangiocarcinoma Cells. Int J Mol Sci. 2024;25: pubmed publisher
Yang H, Sun B, Fan L, Ma W, Xu K, Hall S, et al. Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma. Theranostics. 2022;12:3104-3130 pubmed publisher
Cartee N, Lee S, Keep S, Wang M. Context-dependent monoclonal antibodies against protein carbamidomethyl-cysteine. PLoS ONE. 2020;15:e0242376 pubmed publisher
Liu J, Chen P, Chang T, Hou C. Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF-κB activation. J Cell Mol Med. 2020;24:12826-12839 pubmed publisher
Inana G, Murat C, An W, Yao X, Harris I, Cao J. RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. J Transl Med. 2018;16:63 pubmed publisher
Roudnicky F, Yoon S, Poghosyan S, Schwager S, Poyet C, Vella G, et al. Alternative transcription of a shorter, non-anti-angiogenic thrombospondin-2 variant in cancer-associated blood vessels. Oncogene. 2018;37:2573-2585 pubmed publisher
Wang S, Hu T, Wang Z, Li N, Zhou L, Liao L, et al. Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure. PLoS ONE. 2017;12:e0185388 pubmed publisher
Chen P, Tang C, Lin L, Tsai C, Chu C, Lin T, et al. Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression. J Hematol Oncol. 2017;10:33 pubmed publisher
Hellbach N, Weise S, Vezzali R, Wahane S, Heidrich S, Roidl D, et al. Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014;23:6177-90 pubmed publisher
Benner E, Luciano D, Jo R, Abdi K, Paez Gonzalez P, Sheng H, et al. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature. 2013;497:369-73 pubmed publisher
product information
brand :
R&D Systems
master code :
1635-T2
SKU :
1635-T2-050
product name :
Recombinant Human Thrombospondin-2 Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human Thrombospondin-2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Thrombospondin-2 Protein, CF has been validated for the following applications: Bioactivity.
target :
Thrombospondin-2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
170-176 kDa, reducing conditions
theoretical molecular weight :
129 kDa
gene symbol :
THBS2
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of SVEC4-10 mouse vascular endothelial cells. . The ED50 for this effect is 0.07-0.7 ╡g/mL. .
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Thrombospondin-2 Protein Bioactivity
accessionNumbers :
P35442
applications :
Bioactivity
source :
NS0-derived Recombinant Human Thrombospondin-2 Protein, CF
USD :
432 USD
alt names :
THBS2, thrombospondin 2, Thrombospondin2, TSP-2, TSP2thrombospondin-2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.