Recombinant Human WISP-1/CCN4 Protein, CF | R&D Systems 1627-WS-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human WISP-1/CCN4 Protein, CF

catalog :

1627-WS-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Fernandez Ruiz R, García Alamán A, Esteban Y, Mir Coll J, Serra Navarro B, Fontcuberta PiSunyer M, et al. Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells. Nat Commun. 2020;11:5982 pubmed publisher
Wright L, Herr D, Brown S, Kasiganesan H, Menick D. Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling. JCI Insight. 2018;3: pubmed publisher
Kokabu S, Rosen V. BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling. FEBS Open Bio. 2018;8:168-176 pubmed publisher
Batsali A, Pontikoglou C, Koutroulakis D, Pavlaki K, Damianaki A, Mavroudi I, et al. Differential expression of cell cycle and WNT pathway-related genes accounts for differences in the growth and differentiation potential of Wharton's jelly and bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2017;8:102 pubmed publisher
Li F, Wang X, Zhou X. WISP-1 overexpression upregulates cell proliferation in human salivary gland carcinomas via regulating MMP-2 expression. Onco Targets Ther. 2016;9:6539-6548 pubmed
Liu Z, Li Y, Tan Y, Xiao M, Zhang J, Radtke F, et al. Inhibition of fibroblast growth by Notch1 signaling is mediated by induction of Wnt11-dependent WISP-1. PLoS ONE. 2012;7:e38811 pubmed publisher
Shao H, Cai L, Grichnik J, Livingstone A, Velazquez O, Liu Z. Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1. Oncogene. 2011;30:4316-26 pubmed publisher

product information

master code :

1627-WS

SKU :

1627-WS-050

product name :

Recombinant Human WISP-1/CCN4 Protein, CF

unit size :

50 ug

description :

The Recombinant Human WISP-1/CCN4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human WISP-1/CCN4 Protein, CF has been validated for the following applications: Bioactivity.

target :

WISP-1/CCN4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

62 kDa, reducing conditions

theoretical molecular weight :

39.3 kDa

gene symbol :

WISP1

details of functionality :

Measured by its ability to inhibit the cell growth of DU145 human prostate carcinoma cells. The ED50 for this effect is 6.00 ╡g/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O95388

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human WISP-1/CCN4 protein Thr23-Asn367, with a 10-His tag

source short :

NS0

USD :

432 USD

alt names :

CCN family member 4, CCN4, CCN4WISP1tc, WISP1, WISP-1, WISP1c, WISP1i, WNT1 induced secreted protein 1, Wnt-1 inducible signaling pathway protein 1, WNT1 inducible signaling pathway protein 1, wnt-1 signaling pathway protein 1, Wnt-1-induced secreted protein, WNT1-inducible-signaling pathway protein 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage