Recombinant Human Frizzled-5 Fc Chimera Protein, CF | R&D Systems 1617-FZ-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Frizzled-5 Fc Chimera Protein, CF

catalog :

1617-FZ-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher
Ramirez V, Ramos Fernández E, Henriquez J, Lorenzo A, Inestrosa N. Wnt-5a/Frizzled9 Receptor Signaling through the G?o-G?? Complex Regulates Dendritic Spine Formation. J Biol Chem. 2016;291:19092-107 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Magdesian M, Carvalho M, Mendes F, Saraiva L, Juliano M, Juliano L, et al. Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem. 2008;283:9359-68 pubmed publisher
Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, et al. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood. 2006;108:965-73 pubmed

product information

brand :

R&D Systems

master code :

1617-FZ

SKU :

1617-FZ-050

product name :

Recombinant Human Frizzled-5 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human Frizzled-5 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Frizzled-5 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Frizzled-5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

55-60 kDa, reducing conditions

theoretical molecular weight :

42.5 kDa (monomer)

gene symbol :

FZD5

details of functionality :

Measured by its ability to bind biotinylated Wnt-5a in a functional ELISA with an estimated Kd 1.5 nM.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAC50385

applications :

Binding Activity

source :

NS0-derived Recombinant Human Frizzled-5 Fc Chimera Protein, CF

USD :

432 USD

alt names :

C2orf31, chromosome 2 open reading frame 31, DKFZP434E2135, frizzled (Drosophila) homolog 5, frizzled homolog 5 (Drosophila), frizzled-5, Frizzled5, Frz-5, FZ-5, FZD5, FzE5, HFZ5, MGC129692, seven-transmembrane receptor frizzled-5, Wnt receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage