Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF | R&D Systems 1600-R2-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF

catalog :

1600-R2-050

quantity :

50 ug

price :

480 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Li Y, Wang J, Asahina K. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013;110:2324-9 pubmed publisher
Garidou L, Heydari S, Gossa S, McGavern D. Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection. J Virol. 2012;86:7060-71 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Kissick H, Ireland D, Beilharz M. Combined intratumoral regulatory T-cell depletion and transforming growth factor-? neutralization induces regression of established AE17 murine mesothelioma tumors. J Interferon Cytokine Res. 2009;29:209-15 pubmed publisher
Seki E, De Minicis S, Osterreicher C, Kluwe J, Osawa Y, Brenner D, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13:1324-32 pubmed

product information

brand :

R&D Systems

master code :

1600-R2

SKU :

1600-R2-050

product name :

Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF

unit size :

50 ug

seo description :

The Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF from R&D Systems is derived from NS0. The Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF has been validated for the following applications: Bioactivity.

target :

TGF-beta RII

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

66 kDa, reducing conditions

theoretical molecular weight :

45.2 kDa (monomer)

gene symbol :

Tgfbr2

details of functionality :

Measured by its ability to inhibit TGF┐▀1 activity on HT-2 mouse T cells. Tsang,áM. etáal . (1995) Cytokine 7 :389. The ED50 for this effect is 3-10 ng/mL in the presence of 1 ng/mL of rhTGF┐▀1.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q62312

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse TGF-beta RII/(mouse) Fc Chimera, CF

USD :

480 USD

alt names :

AAT3, EC 2.7.11, EC 2.7.11.30, FAA3, HNPCC6, LDS1B, LDS2B, MFS2, RIIC, TAAD2, tbetaR-II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGF-beta receptor type-2, TGF-beta type II receptor, TGFbetaRII, TGFbeta-RII, TGFBR2, TGF-bRII, TGFR-2, transforming growth factor beta receptor type IIC, transforming growth factor, beta receptor II (70/80kDa), transforming growth factor, beta receptor II (70/80kDa) isoform 1, transforming growth factor, beta receptor II (70/80kDa) isoform 2, transforming growth factor, beta receptor II (70-80kD), Transforming growth factor-beta receptor type II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage