Recombinant Human MICB (aa 23-298) Fc Chimera Protein, CF | R&D Systems 1599-MB-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MICB (aa 23-298) Fc Chimera Protein, CF

catalog :

1599-MB-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Seller A, Tegeler C, Mauermann J, Schreiber T, Hagelstein I, Liebel K, et al. Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome. Int J Mol Sci. 2024;25: pubmed publisher
Myers J, Schirm D, Bendzick L, Hopps R, Selleck C, Hinderlie P, et al. Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion. JCI Insight. 2022;7: pubmed publisher
Weil S, Memmer S, Lechner A, Huppert V, Giannattasio A, Becker T, et al. Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma. Front Immunol. 2017;8:387 pubmed publisher
Raneros A, Puras A, Rodriguez R, Colado E, Bernal T, Anguita E, et al. Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition. Oncotarget. 2017;8:31959-31976 pubmed publisher
Kwong K, Baskar S, Zhang H, Mackall C, Rader C. Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity. J Mol Biol. 2008;384:1143-56 pubmed publisher
Spreu J, Stehle T, Steinle A. Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their alpha2 domains. J Immunol. 2006;177:3143-9 pubmed

product information

brand :

R&D Systems

master code :

1599-MB

SKU :

1599-MB-050

product name :

Recombinant Human MICB (aa 23-298) Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human MICB (aa 23-298) Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MICB (aa 23-298) Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

MICB

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

82 kDa, reducing conditions

theoretical molecular weight :

58 kDa

gene symbol :

MICB

details of functionality :

Measured by its ability to bind rhNKG2D/Fc Chimera in a functional ELISA.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_005922

applications :

Binding Activity

source :

NS0-derived Recombinant Human MICB (aa 23-298) Fc Chimera Protein, CF

USD :

432 USD

alt names :

MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I polypeptide-related sequence B, MIC-B, PERB11.2MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage