This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-29/IFN-lambda 1 Protein
catalog :
1598-IL
quantity :
25 ug
price :
329 USD
citations: 29
Reference
Chung J, Hong S, Seo N, Kim T, An H, Lee P, et al. Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency. Cytokine. 2020;125:154833 pubmed publisher
Good C, Wells A, Coyne C. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019;5:eaau4255 pubmed publisher
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
Angelidou I, Chrysanthopoulou A, Mitsios A, Arelaki S, Arampatzioglou A, Kambas K, et al. REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1β Inflammatory Response in Active Ulcerative Colitis. J Immunol. 2018;200:3950-3961 pubmed publisher
Pierangeli A, Statzu M, Nenna R, Santinelli L, Petrarca L, Frassanito A, et al. Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity. J Clin Virol. 2018;102:101-109 pubmed publisher
Kwek S, Watanabe S, Chan K, Ong E, Tan H, Ng W, et al. A systematic approach to the development of a safe live attenuated Zika vaccine. Nat Commun. 2018;9:1031 pubmed publisher
Obajemu A, Rao N, Dilley K, Vargas J, Sheikh F, Donnelly R, et al. IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling. J Immunol. 2017;199:3808-3820 pubmed publisher
Corry J, Arora N, Good C, Sadovsky Y, Coyne C. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2017;114:9433-9438 pubmed publisher
Ilyushina N, Lugovtsev V, Samsonova A, Sheikh F, Bovin N, Donnelly R. Generation and characterization of interferon-lambda 1-resistant H1N1 influenza A viruses. PLoS ONE. 2017;12:e0181999 pubmed publisher
Sung P, Hong S, Chung J, Kim S, Park S, Kim H, et al. IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep. 2017;7:3821 pubmed publisher
Oke V, Brauner S, Larsson A, Gustafsson J, Zickert A, Gunnarsson I, et al. IFN-?1 with Th17 axis cytokines and IFN-? define different subsets in systemic lupus erythematosus (SLE). Arthritis Res Ther. 2017;19:139 pubmed publisher
Zickert A, Oke V, Parodis I, Svenungsson E, Sundström Y, Gunnarsson I. Interferon (IFN)-λ is a potential mediator in lupus nephritis. Lupus Sci Med. 2016;3:e000170 pubmed
Jarret A, McFarland A, Horner S, Kell A, Schwerk J, Hong M, et al. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. Nat Med. 2016;22:1475-1481 pubmed publisher
Hsu Y, Wang M, Ho L, Lai J. Dengue virus infection induces interferon-lambda1 to facilitate cell migration. Sci Rep. 2016;6:24530 pubmed publisher
Bordi L, Lalle E, Caglioti C, Travaglini D, Lapa D, Marsella P, et al. Antagonistic antiviral activity between IFN-lambda and IFN-alpha against lethal Crimean-Congo hemorrhagic fever virus in vitro. PLoS ONE. 2015;10:e0116816 pubmed publisher
Ding S, Khoury Hanold W, Iwasaki A, Robek M. Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. PLoS Biol. 2014;12:e1001758 pubmed publisher
Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, et al. IL-27, a cytokine, and IFN-?1, a type III IFN, are coordinated to regulate virus replication through type I IFN. J Immunol. 2014;192:691-703 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Popugaeva E, Witkowski P, Schlegel M, Ulrich R, Auste B, Rang A, et al. Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE. 2012;7:e35587 pubmed publisher
Li Q, Kawamura K, Okamoto S, Fujie H, Numasaki M, Namba M, et al. Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-? genes produced anti-tumour effects. Br J Cancer. 2011;105:1302-12 pubmed publisher
Zahn S, Rehkämper C, Kummerer B, Ferring Schmidt S, Bieber T, Tüting T, et al. Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN?) in cutaneous lupus erythematosus. J Invest Dermatol. 2011;131:133-40 pubmed publisher
Prescott J, Hall P, Acuna Retamar M, Ye C, Wathelet M, Ebihara H, et al. New World hantaviruses activate IFNlambda production in type I IFN-deficient vero E6 cells. PLoS ONE. 2010;5:e11159 pubmed publisher
Witte K, Gruetz G, Volk H, Looman A, Asadullah K, Sterry W, et al. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun. 2009;10:702-14 pubmed publisher
Bin L, Howell M, Kim B, Hall C, Streib J, Leung D. Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain. J Allergy Clin Immunol. 2009;124:270-7, 277.e1 pubmed publisher
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, et al. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer. 2009;125:367-73 pubmed publisher
Kato A, Peters A, Suh L, Carter R, Harris K, Chandra R, et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2008;121:1385-92, 1392.e1-2 pubmed publisher
Wolk K, Witte K, Witte E, Proesch S, Schulze Tanzil G, Nasilowska K, et al. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J Leukoc Biol. 2008;83:1181-93 pubmed publisher
Kato A, Favoreto S, Avila P, Schleimer R. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol. 2007;179:1080-7 pubmed
Meager A, Visvalingam K, Dilger P, Bryan D, Wadhwa M. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine. 2005;31:109-18 pubmed
product information
brand :
R&D Systems
master code :
1598-IL
SKU :
1598-IL-025
product name :
Recombinant Human IL-29/IFN-lambda 1 Protein
description :
The Recombinant Human IL-29/IFN-lambda 1 Protein from R&D Systems is derived from NS0. The Recombinant Human IL-29/IFN-lambda 1 Protein has been validated for the following applications: Bioactivity.
target :
IL-29/IFN-lambda 1
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
26-35 kDa, reducing conditions
theoretical molecular weight :
21.4 kDa
gene symbol :
IFNL1
details of functionality :
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 1-5 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
1598-IL
accessionNumbers :
Q8IU54
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human IL-29/IFN-lambda 1 protein Gly20-Thr200, with a C-terminal 10-His tag
2020 USD :
329
2021 USD :
329 USD
alt names :
cytokine Zcyto21, IFNL1, IFN-lambda 1, IFN-lambda-1, IL29, IL-29, interferon lambda-1, interferon, lambda 1, interleukin 29 (interferon, lambda 1), interleukin-29, ZCYTO21
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.