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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-29/IFN-lambda 1 Protein, CF
catalog :
1598-IL-025/CF
quantity :
25 ug
price :
400 USD
more info or order :
citations: 42
Reference
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Hawerkamp H, Domdey A, Radau L, Sewerin P, Oláh P, Homey B, et al. Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation. Arthritis Res Ther. 2021;23:144 pubmed publisher
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub J, Klute S, et al. Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities. Cell Rep. 2021;35:109126 pubmed publisher
Zhao X, Li C, Liu X, Chiu M, Wang D, Wei Y, et al. Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus. Stem Cell Reports. 2021;16:493-504 pubmed publisher
Syedbasha M, Bonfiglio F, Linnik J, Stuehler C, Wüthrich D, Egli A. Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway. Cell Rep. 2020;33:108211 pubmed publisher
Stairiker C, van Meurs M, Leon L, Brouwers Haspels A, Rijsbergen L, Mueller Y, et al. Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells. PLoS ONE. 2020;15:e0236195 pubmed publisher
Essaidi Laziosi M, Geiser J, Huang S, Constant S, Kaiser L, Tapparel C. Interferon-Dependent and Respiratory Virus-Specific Interference in Dual Infections of Airway Epithelia. Sci Rep. 2020;10:10246 pubmed publisher
Chen Y, Wang Y, Tang R, Yang J, Dou C, Dong Y, et al. Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis. Cell Death Dis. 2020;11:414 pubmed publisher
Kell A, Hemann E, Turnbull J, Gale M. RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication. PLoS Pathog. 2020;16:e1008483 pubmed publisher
Chung J, Hong S, Seo N, Kim T, An H, Lee P, et al. Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency. Cytokine. 2020;125:154833 pubmed publisher
Good C, Wells A, Coyne C. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019;5:eaau4255 pubmed publisher
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
Angelidou I, Chrysanthopoulou A, Mitsios A, Arelaki S, Arampatzioglou A, Kambas K, et al. REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1β Inflammatory Response in Active Ulcerative Colitis. J Immunol. 2018;200:3950-3961 pubmed publisher
Pierangeli A, Statzu M, Nenna R, Santinelli L, Petrarca L, Frassanito A, et al. Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity. J Clin Virol. 2018;102:101-109 pubmed publisher
Kwek S, Watanabe S, Chan K, Ong E, Tan H, Ng W, et al. A systematic approach to the development of a safe live attenuated Zika vaccine. Nat Commun. 2018;9:1031 pubmed publisher
Obajemu A, Rao N, Dilley K, Vargas J, Sheikh F, Donnelly R, et al. IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling. J Immunol. 2017;199:3808-3820 pubmed publisher
Corry J, Arora N, Good C, Sadovsky Y, Coyne C. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2017;114:9433-9438 pubmed publisher
Ilyushina N, Lugovtsev V, Samsonova A, Sheikh F, Bovin N, Donnelly R. Generation and characterization of interferon-lambda 1-resistant H1N1 influenza A viruses. PLoS ONE. 2017;12:e0181999 pubmed publisher
Sung P, Hong S, Chung J, Kim S, Park S, Kim H, et al. IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep. 2017;7:3821 pubmed publisher
Oke V, Brauner S, Larsson A, Gustafsson J, Zickert A, Gunnarsson I, et al. IFN-?1 with Th17 axis cytokines and IFN-? define different subsets in systemic lupus erythematosus (SLE). Arthritis Res Ther. 2017;19:139 pubmed publisher
Zickert A, Oke V, Parodis I, Svenungsson E, Sundström Y, Gunnarsson I. Interferon (IFN)-λ is a potential mediator in lupus nephritis. Lupus Sci Med. 2016;3:e000170 pubmed
Jarret A, McFarland A, Horner S, Kell A, Schwerk J, Hong M, et al. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. Nat Med. 2016;22:1475-1481 pubmed publisher
Hsu Y, Wang M, Ho L, Lai J. Dengue virus infection induces interferon-lambda1 to facilitate cell migration. Sci Rep. 2016;6:24530 pubmed publisher
Bordi L, Lalle E, Caglioti C, Travaglini D, Lapa D, Marsella P, et al. Antagonistic antiviral activity between IFN-lambda and IFN-alpha against lethal Crimean-Congo hemorrhagic fever virus in vitro. PLoS ONE. 2015;10:e0116816 pubmed publisher
Ding S, Khoury Hanold W, Iwasaki A, Robek M. Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. PLoS Biol. 2014;12:e1001758 pubmed publisher
Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, et al. IL-27, a cytokine, and IFN-?1, a type III IFN, are coordinated to regulate virus replication through type I IFN. J Immunol. 2014;192:691-703 pubmed publisher
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Li Q, Kawamura K, Okamoto S, Fujie H, Numasaki M, Namba M, et al. Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-? genes produced anti-tumour effects. Br J Cancer. 2011;105:1302-12 pubmed publisher
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Witte K, Gruetz G, Volk H, Looman A, Asadullah K, Sterry W, et al. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun. 2009;10:702-14 pubmed publisher
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product information
brand :
R&D Systems
master code :
1598-IL/CF
SKU :
1598-IL-025/CF
product name :
Recombinant Human IL-29/IFN-lambda 1 Protein, CF
unit size :
25 ug
seo description :
The Recombinant Human IL-29/IFN-lambda 1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-29/IFN-lambda 1 Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-29/IFN-lambda 1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
26-35 kDa, reducing conditions
theoretical molecular weight :
21.4 kDa
gene symbol :
IFNL1
details of functionality :
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 1-5 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q8IU54
applications :
Bioactivity
source :
NS0-derived Recombinant Human IL-29/IFN-lambda 1 Protein, CF
USD :
400 USD
alt names :
cytokine Zcyto21, IFNL1, IFN-lambda 1, IFN-lambda-1, IL29, IL-29, interferon lambda-1, interferon, lambda 1, interleukin 29 (interferon, lambda 1), interleukin-29, ZCYTO21
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.