Recombinant Mouse SOST/Sclerostin Protein, CF | R&D Systems 1589-ST-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse SOST/Sclerostin Protein, CF

catalog :

1589-ST-025/CF

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Miyatake K, Kumagai K, Imai S, Yamaguchi Y, Inaba Y. Sclerostin inhibits interleukin-1β-induced late stage chondrogenic differentiation through downregulation of Wnt/β-catenin signaling pathway. PLoS ONE. 2020;15:e0239651 pubmed publisher
Nordberg R, Mellor L, Krause A, Donahue H, Loboa E. LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure. PLoS ONE. 2019;14:e0223245 pubmed publisher
Yamaguchi Y, Kumagai K, Imai S, Miyatake K, Saito T. Sclerostin is upregulated in the early stage of chondrogenic differentiation, but not required in endochondral ossification in vitro. PLoS ONE. 2018;13:e0201839 pubmed publisher
Johnson M, Konicke K, Kristianto J, Gustavson A, Garbo R, Wang X, et al. Endothelin signaling regulates mineralization and posttranscriptionally regulates SOST in TMOb cells via miR 126-3p. Physiol Rep. 2017;5: pubmed publisher
Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, et al. Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/Î²-CATENIN SIGNALING PATHWAY. J Biol Chem. 2015;290:18216-26 pubmed publisher
Ryan Z, Ketha H, McNulty M, MCGEE LAWRENCE M, Craig T, Grande J, et al. Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium. Proc Natl Acad Sci U S A. 2013;110:6199-204 pubmed publisher

product information

brand :

R&D Systems

master code :

1589-ST/CF

SKU :

1589-ST-025/CF

product name :

Recombinant Mouse SOST/Sclerostin Protein, CF

unit size :

25 ug

seo description :

The Recombinant Mouse SOST/Sclerostin Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse SOST/Sclerostin Protein, CF has been validated for the following applications: Bioactivity.

target :

SOST/Sclerostin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

30 kDa, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

Sost

details of functionality :

Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 1-5 ╡g/mL in the presence of Recombinant Mouse Wnt-3a (Catalog # 1324-WN ).

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_077769

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse SOST/Sclerostin Protein, CF

USD :

432 USD

alt names :

sclerostin, VBCHsclerosteosis

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage