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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-28A/IFN-lambda 2 Protein
catalog :
1587-IL-025
quantity :
25 ug
price :
400 USD
more info or order :
citations: 13
Reference
Syedbasha M, Bonfiglio F, Linnik J, Stuehler C, Wüthrich D, Egli A. Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway. Cell Rep. 2020;33:108211 pubmed publisher
Pierangeli A, Statzu M, Nenna R, Santinelli L, Petrarca L, Frassanito A, et al. Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity. J Clin Virol. 2018;102:101-109 pubmed publisher
Corry J, Arora N, Good C, Sadovsky Y, Coyne C. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2017;114:9433-9438 pubmed publisher
Sung P, Hong S, Chung J, Kim S, Park S, Kim H, et al. IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep. 2017;7:3821 pubmed publisher
Jarret A, McFarland A, Horner S, Kell A, Schwerk J, Hong M, et al. Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. Nat Med. 2016;22:1475-1481 pubmed publisher
Persson B, Jaffe A, Fearns R, Danahay H. Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. PLoS ONE. 2014;9:e102368 pubmed publisher
Ding S, Khoury Hanold W, Iwasaki A, Robek M. Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. PLoS Biol. 2014;12:e1001758 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Lee S, Lim J, Choi Y, Kim W, Moon S. Interleukin-28A triggers wound healing migration of bladder cancer cells via NF-?B-mediated MMP-9 expression inducing the MAPK pathway. Cell Signal. 2012;24:1734-42 pubmed publisher
Li Q, Kawamura K, Okamoto S, Fujie H, Numasaki M, Namba M, et al. Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon-? genes produced anti-tumour effects. Br J Cancer. 2011;105:1302-12 pubmed publisher
Witte K, Gruetz G, Volk H, Looman A, Asadullah K, Sterry W, et al. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun. 2009;10:702-14 pubmed publisher
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, et al. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer. 2009;125:367-73 pubmed publisher
Meager A, Visvalingam K, Dilger P, Bryan D, Wadhwa M. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine. 2005;31:109-18 pubmed
product information
master code :
1587-IL
SKU :
1587-IL-025
product name :
Recombinant Human IL-28A/IFN-lambda 2 Protein
unit size :
25 ug
description :
The Recombinant Human IL-28A/IFN-lambda 2 Protein from R&D Systems is derived from NS0. The Recombinant Human IL-28A/IFN-lambda 2 Protein has been validated for the following applications: Bioactivity.
target :
IL-28A/IFN-lambda 2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
24 kDa, reducing conditions
theoretical molecular weight :
20.8 kDa
gene symbol :
IFNL2
details of functionality :
Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al . (2003) Nat. Immunol. 4 :63. The ED50 for this effect is 0.800-8.00 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
NP_742150
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human IL-28A/IFN-lambda 2 protein Human IL-28A Val26-Val200 Accession # NP_742150 DI 6-His tag N-terminus C-terminus
source short :
NS0
USD :
400 USD
alt names :
interleukin-28A, IFN-lambda 2, IL28A, IL-28A, interferon, lambda 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.