Recombinant Human Enteropeptidase/Enterokinase Protein, CF | R&D Systems 1585-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Enteropeptidase/Enterokinase Protein, CF

catalog :

1585-SE-010

quantity :

10 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Pesei Z, Jancs xf3 Z, Demcs xe1 k A, N xe9 meth B, Vajda S, Sahin T xf3 th M. Preclinical testing of dabigatran in trypsin-dependent pancreatitis. JCI Insight. 2022;7: pubmed publisher
Toldi V, Szabo A, Sahin Toth M. Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation. J Biol Chem. 2020;295:3447-3455 pubmed publisher
Geisz A, Jancsó Z, Németh B, Hegyi E, Sahin Toth M. Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice. JCI Insight. 2019;4:e129717 pubmed publisher
Hegyi E, Sahin Toth M. Trypsinogen isoforms in the ferret pancreas. Sci Rep. 2018;8:15094 pubmed publisher
Szabo A, Radisky E, Sahin Toth M. Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation. J Biol Chem. 2014;289:4753-61 pubmed publisher
Németh B, Wartmann T, Halangk W, Sahin Toth M. Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop. J Biol Chem. 2013;288:24049-62 pubmed publisher
Prohaska T, Wahlmüller F, Furtmüller M, Geiger M. Interaction of protein C inhibitor with the type II transmembrane serine protease enteropeptidase. PLoS ONE. 2012;7:e39262 pubmed publisher
Nemoda Z, Sahin Toth M. Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen. J Biol Chem. 2006;281:11879-86 pubmed

product information

brand :

R&D Systems

master code :

1585-SE

SKU :

1585-SE-010

product name :

Recombinant Human Enteropeptidase/Enterokinase Protein, CF

unit size :

10 ug

seo description :

The Recombinant Human Enteropeptidase/Enterokinase Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Enteropeptidase/Enterokinase Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Enteropeptidase/Enterokinase

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris, NaCl and CaCl2.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

150 kDa, reducing conditions

theoretical molecular weight :

110 kDa

gene symbol :

TMPRSS15

details of functionality :

Measured by its ability to cleave a colorimetric peptide substrate, Z-Lys-SBzl. The specific activity is 10,000 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P98073

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human Enteropeptidase/Enterokinase Protein, CF

USD :

400 USD

alt names :

EC 3.4.21, EC 3.4.21.9, Enterokinase, ENTK, ENTKenterokinase, MGC133046, protease, serine, 7 (enterokinase), PRSS7, PRSS7enteropeptidase, Serine protease 7, TMPRSS15, Transmembrane protease serine 15, transmembrane protease, serine 15

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage