Recombinant Mouse Hip Protein | R&D Systems 1568-HP-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Hip Protein

catalog :

1568-HP-050

quantity :

50 ug

price :

498 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Caligiuri S, Howe W, Wills L, Smith A, Lei Y, Bali P, et al. Hedgehog-interacting protein acts in the habenula to regulate nicotine intake. Proc Natl Acad Sci U S A. 2022;119:e2209870119 pubmed publisher
Zhao X, Chang S, Liao M, Lo C, Chenier I, Luo H, et al. Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes. Sci Rep. 2018;8:5958 pubmed publisher
Kobune M, Iyama S, Kikuchi S, Horiguchi H, Sato T, Murase K, et al. Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms. Blood Cancer J. 2012;2:e87 pubmed publisher
Kayed H, Kleeff J, Esposito I, Giese T, Keleg S, Giese N, et al. Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. Mol Carcinog. 2005;42:183-92 pubmed

product information

master code :

1568-HP

SKU :

1568-HP-050

product name :

Recombinant Mouse Hip Protein

unit size :

50 ug

description :

The Recombinant Mouse Hip Protein from R&D Systems is derived from NS0. The Recombinant Mouse Hip Protein has been validated for the following applications: Bioactivity.

target :

Hip

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

80-90 kDa and 58-64 kDa, reducing conditions

theoretical molecular weight :

76 kDa 73 kDa

gene symbol :

Hhip

details of functionality :

Measured by its ability to inhibit Sonic Hedgehog (Shh) induction of alkaline phosphatase production in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is 1.5-7.5 ╡g/mL in the presence of 5 ╡g/mL rmShh.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAD31172

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse Hip protein Mouse Hip (Lys24 - Arg678 Asp52 - Arg678) Accession # AAD31172 IEGRMDGGGSGGGSGGGS 10-His tag N-terminus C-terminus

source short :

NS0

USD :

498 USD

alt names :

FLJ90230, hedgehog interacting protein, hedgehog-interacting protein, HHIP, HIPFLJ20992

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage