Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF | R&D Systems 1559-NT-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF

catalog :

1559-NT-050

quantity :

50 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Kim H, Jang B, Kim Y, Choi J. Determination of Blood NOTCH3 Extracellular Domain and Jagged-1 Levels in Healthy Subjects. Int J Mol Sci. 2022;23: pubmed publisher
Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, et al. NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma. PLoS ONE. 2016;11:e0154112 pubmed publisher
Scehnet J, Jiang W, Kumar S, Krasnoperov V, Trindade A, Benedito R, et al. Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood. 2007;109:4753-60 pubmed

product information

master code :

1559-NT

SKU :

1559-NT-050

product name :

Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (stably transfected). The Recombinant Human Notch-3 (aa 40-467) Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Notch-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

85-95 kDa, reducing conditions

theoretical molecular weight :

71.4 kDa (monomer)

gene symbol :

NOTCH3

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rhNotch-3/Fc Chimera can bind rrJagged-1/Fc Chimera with an apparent KD 10 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9UM47

applications :

Binding Activity

source long :

Spodoptera frugiperda , Sf 21 (stably transfected)-derived human Notch-3 protein Human Notch-3 (Ala40 - Glu467) Accession # Q9UM47 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

Sf 21 (stably transfected)

USD :

456 USD

alt names :

CADASIL, CASILneurogenic locus notch homolog protein 3, Notch (Drosophila) homolog 3, notch 3Notch homolog 3 (Drosophila), Notch homolog 3, Notch3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage