Recombinant Rat IL-1ra/IL-1F3 Protein | R&D Systems 1545-RA-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat IL-1ra/IL-1F3 Protein

catalog :

1545-RA-025

quantity :

25 ug

price :

456 USD

citations: 13

Reference
Sancho Alonso M, Arenas Y, Izquierdo Altarejos P, Martinez Garcia M, Llansola M, Felipo V. Enhanced Activation of the S1PR2-IL-1β-Src-BDNF-TrkB Pathway Mediates Neuroinflammation in the Hippocampus and Cognitive Impairment in Hyperammonemic Rats. Int J Mol Sci. 2023;24: pubmed publisher
Sanchez J, Sanchez J, Noor S, Ruffaner Hanson C, Davies S, Wagner C, et al. Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure. Acta Neuropathol Commun. 2019;7:54 pubmed publisher
Taoro Gonzalez L, Arenas Y, Cabrera Pastor A, Felipo V. Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms. J Neuroinflammation. 2018;15:36 pubmed publisher
Chentouf M, Guzman C, Hamze M, Gross R, Lajoix A, Peraldi Roux S. Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells. PLoS ONE. 2014;9:e102889 pubmed publisher
Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, et al. A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats. J Neurosci. 2014;34:9779-88 pubmed publisher
Yamato M, Tamura Y, Eguchi A, Kume S, Miyashige Y, Nakano M, et al. Brain interleukin-1? and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats. PLoS ONE. 2014;9:e90950 pubmed publisher
Sato K, Horiuchi Y, Jin Y, Malchinkhuu E, Komachi M, Kondo T, et al. Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1?-induced attenuation of Rho signaling pathways in rat astrocytes. J Neurochem. 2011;117:164-74 pubmed publisher
Lapierre D, Tanabe N, Pereverzev A, Spencer M, Shugg R, Dixon S, et al. Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem. 2010;285:25792-801 pubmed publisher
Taepavarapruk P, Song C. Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment. J Neurochem. 2010;112:1054-64 pubmed publisher
Marchi N, Fan Q, Ghosh C, Fazio V, Bertolini F, Betto G, et al. Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis. 2009;33:171-81 pubmed publisher
Koo J, Duman R. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A. 2008;105:751-6 pubmed publisher
Puehler W, Rittner H, Mousa S, Brack A, Krause H, Stein C, et al. Interleukin-1 beta contributes to the upregulation of kappa opioid receptor mrna in dorsal root ganglia in response to peripheral inflammation. Neuroscience. 2006;141:989-98 pubmed
Borsody M, Weiss J. The effects of endogenous interleukin-1 bioactivity on locus coeruleus neurons in response to bacterial and viral substances. Brain Res. 2004;1007:39-56 pubmed

product information

master code :

1545-RA

SKU :

1545-RA-025

product name :

Recombinant Rat IL-1ra/IL-1F3 Protein

unit size :

25 ug

description :

The Recombinant Rat IL-1ra/IL-1F3 Protein from R&D Systems is derived from E. coli. The Recombinant Rat IL-1ra/IL-1F3 Protein has been validated for the following applications: Bioactivity.

target :

IL-1ra/IL-1F3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and DTT with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Rat

theoretical molecular weight :

17.5 kDa

gene symbol :

Il1rn

details of functionality :

Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 38-150 ng/mL in the presence of 50 pg/mL of rrIL-1 alpha .

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P25086.1

applications :

Bioactivity

source long :

E. coli -derived rat IL-1ra/IL-1F3 protein His27-Gln178, with an N-terminal Met

source short :

E. coli

USD :

456 USD

alt names :

DIRA, ICIL-1RA, IL1F3, IL-1F3, IL-1ra, IL1RA, IL-1ra3, IL1RN, IL-1RN, interleukin 1 receptor antagonist, IRAP, MVCD4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.