Recombinant Human Axl Fc Chimera Protein, CF | R&D Systems 154-AL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Axl Fc Chimera Protein, CF

catalog :

154-AL

quantity :

100 ug

price :

359 USD

citations: 8

Reference
Dumas P, Naudin C, Martin Lannerée S, Izac B, Casetti L, Mansier O, et al. Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL. Haematologica. 2019;: pubmed publisher
Cho J, Okuma A, Al Rubaye D, Intisar E, Junghans R, Wong W. Engineering Axl specific CAR and SynNotch receptor for cancer therapy. Sci Rep. 2018;8:3846 pubmed publisher
Park I, Mundy Bosse B, Whitman S, Zhang X, Warner S, Bearss D, et al. Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia. Leukemia. 2015;29:2382-9 pubmed publisher
Zizzo G, Guerrieri J, Dittman L, Merrill J, Cohen P. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther. 2013;15:R212 pubmed
Cerchia L, Esposito C, Camorani S, Rienzo A, Stasio L, Insabato L, et al. Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther. 2012;20:2291-303 pubmed publisher
Ruan G, Kazlauskas A. Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J. 2012;31:1692-703 pubmed publisher
Shimojima M, Stroher U, Ebihara H, Feldmann H, Kawaoka Y. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J Virol. 2012;86:2067-78 pubmed publisher
Sensi M, Catani M, Castellano G, Nicolini G, Alciato F, Tragni G, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011;131:2448-57 pubmed publisher

product information

brand :

R&D Systems

master code :

154-AL

SKU :

154-AL-100

product name :

Recombinant Human Axl Fc Chimera Protein, CF

description :

The Recombinant Human Axl Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Axl Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Axl

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

71.7 kDa (monomer)

gene symbol :

AXL

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human Axl Fc Chimera is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Human Gas6 (Catalog # 885-GS ) that produces 50% of the optimal binding response is approximately 2.5-15 ng/mL.

endotoxin note :

<0.1 EU per 1 µg of the protein by the LAL method.

catalog number base :

154-AL

accessionNumbers :

AAA61243

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human Axl protein Human Axl (Glu33-Pro440) Accession # AAA61243 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

2020 USD :

359

2021 USD :

359 USD

alt names :

AI323647, ARK, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, EC 2.7.10, EC 2.7.10.1, JTK11, Tyro7, tyrosine-protein kinase receptor UFO, UFO, UFOoncogene AXL

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.