product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Axl Fc Chimera Protein, CF
catalog :
154-AL-100
quantity :
100 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Vandewalle N, Satilmis H, Verheye E, Fan R, Wang Y, De Groof T, et al. AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia. Theranostics. 2024;14:2656-2674 pubmed publisher
Hokanson C, Zacco E, Cappuccilli G, Odineca T, Crea R. AXL-Receptor Targeted 14FN3 Based Single Domain Proteins (Pronectins™) from 3 Synthetic Human Libraries as Components for Exploring Novel Bispecific Constructs against Solid Tumors. Biomedicines. 2022;10: pubmed publisher
Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes L, Koenen M, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538 pubmed publisher
Luthria G, Li R, Wang S, Prytyskach M, Kohler R, Lauffenburger D, et al. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020;11:3521 pubmed publisher
Wang S, Li R, Ng T, Luthria G, Oudin M, Prytyskach M, et al. Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020;6:eaaz8521 pubmed publisher
Dumas P, Naudin C, Martin Lannerée S, Izac B, Casetti L, Mansier O, et al. Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL. Haematologica. 2019;: pubmed publisher
Cho J, Okuma A, Al Rubaye D, Intisar E, Junghans R, Wong W. Engineering Axl specific CAR and SynNotch receptor for cancer therapy. Sci Rep. 2018;8:3846 pubmed publisher
Park I, Mundy Bosse B, Whitman S, Zhang X, Warner S, Bearss D, et al. Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia. Leukemia. 2015;29:2382-9 pubmed publisher
Zizzo G, Guerrieri J, Dittman L, Merrill J, Cohen P. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther. 2013;15:R212 pubmed
Cerchia L, Esposito C, Camorani S, Rienzo A, Stasio L, Insabato L, et al. Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther. 2012;20:2291-303 pubmed publisher
Ruan G, Kazlauskas A. Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J. 2012;31:1692-703 pubmed publisher
Shimojima M, Stroher U, Ebihara H, Feldmann H, Kawaoka Y. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J Virol. 2012;86:2067-78 pubmed publisher
Sensi M, Catani M, Castellano G, Nicolini G, Alciato F, Tragni G, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011;131:2448-57 pubmed publisher
product information
master code :
154-AL
SKU :
154-AL-100
product name :
Recombinant Human Axl Fc Chimera Protein, CF
unit size :
100 ug
description :
The Recombinant Human Axl Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Axl Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
Axl
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
100-110 kDa, reducing conditions
theoretical molecular weight :
71.7 kDa (monomer)
gene symbol :
AXL
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human Axl Fc Chimera is immobilized at 2 ╡g/mL (100 ╡L/well), the concentration of Recombinant Human Gas6 (Catalog # 885-GS ) that produces 50% of the optimal binding response is approximately 2.5-15 ng/mL.
endotoxin note :
<0.1 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
AAA61243
applications :
Binding Activity
source long :
Mouse myeloma cell line, NS0-derived human Axl protein Human Axl (Glu33-Pro440) Accession # AAA61243 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
source short :
NS0
USD :
456 USD
alt names :
AI323647, ARK, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, EC 2.7.10, EC 2.7.10.1, JTK11, Tyro7, tyrosine-protein kinase receptor UFO, UFO, UFOoncogene AXL
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.