Recombinant Mouse GDF-8 Propeptide Protein, CF | R&D Systems 1539-PG-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse GDF-8 Propeptide Protein, CF

catalog :

1539-PG-025/CF

quantity :

25 ug

price :

507 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Lee S, Park S, Kim Y. Maltose binding protein-fusion enhances the bioactivity of truncated forms of pig myostatin propeptide produced in E. coli. PLoS ONE. 2017;12:e0174956 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Ohsawa Y, Hagiwara H, Nakatani M, Yasue A, Moriyama K, Murakami T, et al. Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. J Clin Invest. 2006;116:2924-34 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1539-PG/CF

SKU :

1539-PG-025/CF

product name :

Recombinant Mouse GDF-8 Propeptide Protein, CF

Description :

The Recombinant Mouse GDF-8 Propeptide Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse GDF-8 Propeptide Protein, CF has been validated for the following applications: Bioactivity.

target :

GDF-8/Myostatin

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

39 kDa, reducing conditions

theoretical molecular weight :

28.7 kDa

gene symbol :

Mstn

details of functionality :

Measured by its ability to inhibit rmGDF-8 activity in K562 human chronic myelogenous leukemia cells. Thies, R.S. et al . (2001) Growth Factors 18 :251. The ED50 for this effect is 0.05-0.25 µg/mL in the presence of 5 ng/mL of Recombinant Mouse GDF-8/Myostatin. Approximately 1 µg/mL will completely inhibit GDF-8 activity in these cells.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O08689

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse GDF-8 Propeptide Protein

USD :

507 USD

alt names :

GDF8, GDF-8, GDF8growth differentiation factor 8, growth/differentiation factor 8, MSLHP, MSTN, Myostatin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage