Recombinant Human ULBP-3 Fc Chimera Protein, CF | R&D Systems 1517-UL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ULBP-3 Fc Chimera Protein, CF

catalog :

1517-UL-050

quantity :

50 ug

price :

507 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Wirsching H, Zhang H, Szulzewsky F, Arora S, Grandi P, Cimino P, et al. Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma. JCI Insight. 2019;4: pubmed publisher
Weil S, Memmer S, Lechner A, Huppert V, Giannattasio A, Becker T, et al. Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma. Front Immunol. 2017;8:387 pubmed publisher
Raneros A, Puras A, Rodriguez R, Colado E, Bernal T, Anguita E, et al. Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition. Oncotarget. 2017;8:31959-31976 pubmed publisher
Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer E, Cerwenka A, et al. Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids. BMC Cancer. 2015;15:351 pubmed publisher
Mou X, Zhou Y, Jiang P, Zhou T, Jiang Q, Xu C, et al. The regulatory effect of UL-16 binding protein-3 expression on the cytotoxicity of NK cells in cancer patients. Sci Rep. 2014;4:6138 pubmed publisher
Nuckel H, Switala M, Sellmann L, Horn P, Durig J, Duhrsen U, et al. The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia. 2010;24:1152-9 pubmed publisher
Ho V, Vanneman M, Kim H, Sasada T, Kang Y, Pasek M, et al. Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation. Proc Natl Acad Sci U S A. 2009;106:15825-30 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1517-UL

SKU :

1517-UL-050

product name :

Recombinant Human ULBP-3 Fc Chimera Protein, CF

Description :

The Recombinant Human ULBP-3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ULBP-3 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

ULBP-3

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

59 kDa, reducing conditions

theoretical molecular weight :

48.8 kDa (monomer)

gene symbol :

ULBP3

details of functionality :

Measured by its ability to bind with Recombinant Human NKG2D/CD314 Fc Chimera (Catalog # 1299-NK ) in a functional ELISA.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_078794

applications :

Binding Activity

source :

NS0-derived Recombinant Human ULBP-3 Fc Chimera Protein

USD :

507 USD

alt names :

NKG2D ligand 3, RAET1N, UL16 binding protein 3, ULBP3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage