product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human DLL4 His-tag Protein
catalog :
1506-D4-050
quantity :
50 ug
price :
377 USD
more info or order :
R&D Systems product webpage
citations: 22
Reference
Shimizu S, Yoshioka K, Aki S, Takuwa Y. Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells. Sci Rep. 2021;11:5199 pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Fan J, Shen W, Lee S, Mathai A, Zhang R, Xu G, et al. Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivo. Theranostics. 2020;10:7956-7973 pubmed publisher
Lopez Guerra M, Xargay Torrent S, Fuentes P, Roldán J, González Farre B, Rosich L, et al. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells. Oncogene. 2020;39:1185-1197 pubmed publisher
Chung S, Shen W, Davidson K, Pebay A, Wong R, Yau B, et al. Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway. Front Cell Neurosci. 2019;13:527 pubmed publisher
Yetkin Arik B, Vogels I, Neyazi N, van Duinen V, Houtkooper R, Van Noorden C, et al. Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells. Sci Rep. 2019;9:10414 pubmed publisher
Gerli M, Moyle L, Benedetti S, Ferrari G, Ucuncu E, Ragazzi M, et al. Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells. Stem Cell Reports. 2019;12:461-473 pubmed publisher
Kang B, Shin J, Park H, Rhyou C, Kang D, Lee S, et al. High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy. Nat Commun. 2018;9:5402 pubmed publisher
Gocha T, Rao B, DasGupta R. Identification and characterization of a novel Sso7d scaffold-based binder against Notch1. Sci Rep. 2017;7:12021 pubmed publisher
Shah A, Birdsey G, Peghaire C, Pitulescu M, Dufton N, Yang Y, et al. The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability. Nat Commun. 2017;8:16002 pubmed publisher
Antfolk D, Sjöqvist M, Cheng F, Isoniemi K, Duran C, Rivero Muller A, et al. Selective regulation of Notch ligands during angiogenesis is mediated by vimentin. Proc Natl Acad Sci U S A. 2017;114:E4574-E4581 pubmed publisher
You C, Zhao K, Dammann P, Keyvani K, Kreitschmann Andermahr I, Sure U, et al. EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10-ablation. J Cell Mol Med. 2017;21:1848-1858 pubmed publisher
Rama N, Dubrac A, Mathivet T, Ní Chárthaigh R, Genet G, Cristofaro B, et al. Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization. Nat Med. 2015;21:483-91 pubmed publisher
Harjes U, Bridges E, McIntyre A, Fielding B, Harris A. Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells. J Biol Chem. 2014;289:23168-76 pubmed publisher
Sharghi Namini S, Tan E, Ong L, Ge R, Asada H. Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment. Sci Rep. 2014;4:4031 pubmed publisher
Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams R, et al. Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med. 2014;211:281-95 pubmed publisher
Haider S, Meinhardt G, Velicky P, Otti G, Whitley G, Fiala C, et al. Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts. Endocrinology. 2014;155:263-74 pubmed publisher
You C, Sandalcioglu I, Dammann P, Felbor U, Sure U, Zhu Y. Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations. J Cell Mol Med. 2013;17:407-18 pubmed publisher
Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher
Billiard F, Kirshner J, Tait M, Danave A, Taheri S, Zhang W, et al. Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. Eur J Immunol. 2011;41:2207-16 pubmed publisher
Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed publisher
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci N, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008;22:152-65 pubmed publisher
image
image 1 :
R&D Systems 1506-D4-050 image 1
Recombinant Human DLL4 His-tag Protein Bioactivity
product information
brand :
R&D Systems
master code :
1506-D4
SKU :
1506-D4-050
product name :
Recombinant Human DLL4 His-tag Protein
description :
The Recombinant Human DLL4 His-tag Protein from R&D Systems is derived from NS0. The Recombinant Human DLL4 His-tag Protein has been validated for the following applications: Bioactivity.
target :
DLL4
category :
Proteins and Enzymes
unit sizes :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris-HCl, NaCl and PEG 3350 with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
60-70 kDa, reducing conditions
theoretical molecular weight :
55.6 kDa
gene symbol :
DLL4
details of functionality :
Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 150-600 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9NR61
applications :
Bioactivity
source :
NS0-derived Recombinant Human DLL4 His-tag Protein
USD :
377 USD
alt names :
delta 4, Delta 4 precursor, delta ligand 4, delta4, delta-like 4 (Drosophila), delta-like 4 homolog, delta-like 4 homolog (Drosophila), delta-like 4 protein, delta-like protein 4, Drosophila Delta homolog 4, hdelta2, MGC126344, notch ligand delta-2, notch ligand DLL4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.