Recombinant Human LRP-6 Fc Chimera Protein, CF | R&D Systems 1505-LR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human LRP-6 Fc Chimera Protein, CF

catalog :

1505-LR-025

quantity :

25 ug

price :

417 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Jackson H, Granger D, Jones G, Anderson L, Friel S, Rycroft D, et al. Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth. Mol Cancer Res. 2016;14:859-68 pubmed publisher
Gustafson B, Eliasson B, Smith U. Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) inhibitor Dickkopf-1 in adipocytes: a link with osteogenesis. Diabetologia. 2010;53:536-40 pubmed publisher
Liu C, Pearson C, Bu G. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains. J Biol Chem. 2009;284:15299-307 pubmed publisher
Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel Ramoya A, Canalis E. Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem. 2007;282:19762-72 pubmed
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky M, Dwyer D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007;13:156-63 pubmed

product information

brand :

R&D Systems

master code :

1505-LR

SKU :

1505-LR-025

product name :

Recombinant Human LRP-6 Fc Chimera Protein, CF

description :

The Recombinant Human LRP-6 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human LRP-6 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

LRP-6

category :

Proteins and Enzymes

unit sizes :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>80%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

200 kDa, reducing conditions

theoretical molecular weight :

180 kDa (monomer)

gene symbol :

LRP6

details of functionality :

Measured by its binding ability in a functional ELISA. rhLRP-6/Fc Chimera binds rhDkk-1, biotin with an apparent KD 25 nM. Biotinylated rmWnt-3a immobilized on a streptavidin-coated plate at 1 µg/mL can bind rhLRP-6/Fc Chimera with a linear range of 0.2-10 µg/mL. Optimal concentrations should be determined by each laboratory for each application.

endotoxin note :

<0.1 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O75581

applications :

Binding Activity

source :

NS0-derived Recombinant Human LRP-6 Fc Chimera Protein, CF

USD :

417 USD

alt names :

ADCAD2, FLJ90062, FLJ90421, low density lipoprotein receptor-related protein 6, low-density lipoprotein receptor-related protein 6, LRP6, LRP-6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage