Recombinant Human Furin Protein, CF | R&D Systems 1503-SE product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Furin Protein, CF

catalog :

1503-SE

quantity :

10 ug

price :

329 USD

citations: 7

Reference
Benicky J, Sanda M, Brnakova Kennedy Z, Goldman R. N-Glycosylation is required for secretion of the precursor to brain-derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures. J Biol Chem. 2019;294:16816-16830 pubmed publisher
Vassilakos G, Philippou A, Koutsilieris M. Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans. Growth Horm IGF Res. 2017;32:22-28 pubmed publisher
Ferguson T, Reihill J, Walker B, Hamilton R, Martin S. A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. PLoS ONE. 2016;11:e0159868 pubmed publisher
Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
Haage A, Schneider I. Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells. FASEB J. 2014;28:3589-99 pubmed publisher
Bourne G, Grainger D. Development and characterisation of an assay for furin activity. J Immunol Methods. 2011;364:101-8 pubmed publisher
Tsuchiya S, Simmer J, Hu J, Richardson A, Yamakoshi F, Yamakoshi Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). J Bone Miner Res. 2011;26:220-8 pubmed publisher

product information

brand :

R&D Systems

master code :

1503-SE

SKU :

1503-SE-010

product name :

Recombinant Human Furin Protein, CF

description :

The Recombinant Human Furin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Furin Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Furin

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, CaCl2, NaCl, Brij-35 and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

58-85 kDa, reducing conditions

theoretical molecular weight :

67 kDa

gene symbol :

FURIN

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC (Catalog # ES013 ). The specific activity is 125 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1503-SE

accessionNumbers :

P09958

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human Furin protein Asp108-Glu715, with a C-terminal 10-His tag

2020 USD :

329

2021 USD :

329 USD

alt names :

Dibasic-processing enzyme, EC 3.4.21, EC 3.4.21.75, FUR, FURdibasic processing enzyme, furin (paired basic amino acid cleaving enzyme), furin, membrane associated receptor protein, PACE, PACEFES upstream region, paired basic amino acid cleaving enzyme (furin, membrane associated receptorprotein), Paired basic amino acid residue-cleaving enzyme, PC, PCSK3, PCSK3furin, proprotein convertase subtilisin/kexin type 3, SPC1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.