Recombinant Human Furin Protein, CF | R&D Systems 1503-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Furin Protein, CF

catalog :

1503-SE-010

quantity :

10 ug

price :

377 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Shapira T, Monreal I, Dion S, Buchholz D, Imbiakha B, Olmstead A, et al. A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic. Nature. 2022;605:340-348 pubmed publisher
Zaragoza Huesca D, Martínez Cortés C, Banegas Luna A, Pérez Garrido A, Vegara Meseguer J, Peñas Martínez J, et al. Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors. Int J Mol Sci. 2022;23: pubmed publisher
Farrera Soler L, Daguer J, Barluenga S, Vadas O, Cohen P, Pagano S, et al. Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma. PLoS ONE. 2020;15:e0238089 pubmed publisher
Falkowski K, Bielecka E, Thøgersen I, Bocheńska O, Płaza K, Kalińska M, et al. Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis. Int J Mol Sci. 2020;21: pubmed publisher
Benicky J, Sanda M, Brnakova Kennedy Z, Goldman R. N-Glycosylation is required for secretion of the precursor to brain-derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures. J Biol Chem. 2019;294:16816-16830 pubmed publisher
Vassilakos G, Philippou A, Koutsilieris M. Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans. Growth Horm IGF Res. 2017;32:22-28 pubmed publisher
Ferguson T, Reihill J, Walker B, Hamilton R, Martin S. A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. PLoS ONE. 2016;11:e0159868 pubmed publisher
Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
Haage A, Schneider I. Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells. FASEB J. 2014;28:3589-99 pubmed publisher
Bourne G, Grainger D. Development and characterisation of an assay for furin activity. J Immunol Methods. 2011;364:101-8 pubmed publisher
Tsuchiya S, Simmer J, Hu J, Richardson A, Yamakoshi F, Yamakoshi Y. Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). J Bone Miner Res. 2011;26:220-8 pubmed publisher

image

image 1 :

Recombinant Human Furin Protein Enzyme Activity

product information

brand :

R&D Systems

master code :

1503-SE

SKU :

1503-SE-010

product name :

Recombinant Human Furin Protein, CF

description :

The Recombinant Human Furin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Furin Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Furin

category :

Proteins and Enzymes

unit sizes :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, CaCl2, NaCl, Brij-35 and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

58-85 kDa, reducing conditions

theoretical molecular weight :

67 kDa

gene symbol :

FURIN

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC (Catalog # ES013 ). The specific activity is 125 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P09958

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human Furin Protein, CF

USD :

377 USD

alt names :

Dibasic-processing enzyme, EC 3.4.21, EC 3.4.21.75, FUR, FURdibasic processing enzyme, furin (paired basic amino acid cleaving enzyme), furin, membrane associated receptor protein, PACE, PACEFES upstream region, paired basic amino acid cleaving enzyme (furin, membrane associated receptorprotein), Paired basic amino acid residue-cleaving enzyme, PCSK3, PCSK3furin, proprotein convertase subtilisin/kexin type 3, SPC1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage