Recombinant Human CD40/TNFRSF5 Fc Chimera Protein, CF | R&D Systems 1493-CDB-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CD40/TNFRSF5 Fc Chimera Protein, CF

catalog :

1493-CDB-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Yu X, Chan H, Orr C, Dadas O, Booth S, Dahal L, et al. Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies. Cancer Cell. 2018;33:664-675.e4 pubmed publisher
Al Awadhi F, Paul V, Luesch H. Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer. Chembiochem. 2018;19:815-825 pubmed publisher
Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol. 2014;15:354-364 pubmed publisher
Weissmüller S, Semmler L, Kalinke U, Christians S, Muller Berghaus J, Waibler Z. ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation. Blood. 2012;119:6268-77 pubmed publisher
Kaur K, Chowdhury S, Greenspan N, Schreiber J. Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood. 2007;110:2948-54 pubmed

image

image 1 :

Recombinant Human CD40/TNFRSF5 Fc Chimera Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1493-CDB

SKU :

1493-CDB-050

product name :

Recombinant Human CD40/TNFRSF5 Fc Chimera Protein, CF

Description :

The Recombinant Human CD40/TNFRSF5 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human CD40/TNFRSF5 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

CD40/TNFRSF5

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

58-66 kDa, reducing conditions

theoretical molecular weight :

47 kDa

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human CD40/TNFRSF5 Fc Chimera is immobilized at 1 µg/mL (100 µL/well), the concentration of Recombinant Human CD40 Ligand/TNFSF5 (Catalog # 6420-CL ) that produces 50% optimal binding is 4-24 ng/mL. Measured by its ability to inhibit rhCD40 Ligand-induced IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human CD40. The ED50 for this effect is 0.08-0.8 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P25942-1

applications :

Bioactivity

source :

NS0-derived Recombinant Human CD40/TNFRSF5 Fc Chimera Protein

USD :

423 USD

alt names :

B cell surface antigen CD40, B-cell surface antigen CD40, Bp50B cell-associated molecule, CD40, CD40 antigen, CD40 molecule, TNF receptor superfamily member 5, CD40 type II isoform, CD40L receptor, CDw40, MGC9013, nerve growth factor receptor-related B-lymphocyte activation molecule, p50, TNFRSF5, TNFRSF5CD40 antigen (TNF receptor superfamily member 5), tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5

storage :

12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage