Recombinant Human TLR3 Protein, CF | R&D Systems 1487-TR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TLR3 Protein, CF

catalog :

1487-TR-050

quantity :

50 ug

price :

377 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Durai P, Shin H, Achek A, Kwon H, Govindaraj R, Panneerselvam S, et al. Toll-like receptor 2 antagonists identified through virtual screening and experimental validation. FEBS J. 2017;284:2264-2283 pubmed publisher
Toscano F, Estornes Y, Virard F, Garcia Cattaneo A, Pierrot A, Vanbervliet B, et al. Cleaved/associated TLR3 represents the primary form of the signaling receptor. J Immunol. 2013;190:764-73 pubmed publisher
Estornes Y, Toscano F, Virard F, Jacquemin G, Pierrot A, Vanbervliet B, et al. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ. 2012;19:1482-94 pubmed publisher
Perrot I, Deauvieau F, Massacrier C, Hughes N, Garrone P, Durand I, et al. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. J Immunol. 2010;185:2080-8 pubmed publisher
Koarai A, Sugiura H, Yanagisawa S, Ichikawa T, Minakata Y, Matsunaga K, et al. Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells. Am J Respir Cell Mol Biol. 2010;42:651-60 pubmed publisher
Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, et al. Activation of Toll-like receptor 3 augments myofibroblast differentiation. Am J Respir Cell Mol Biol. 2009;40:654-62 pubmed publisher

product information

brand :

R&D Systems

master code :

1487-TR

SKU :

1487-TR-050

product name :

Recombinant Human TLR3 Protein, CF

description :

The Recombinant Human TLR3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TLR3 Protein, CF has been validated for the following applications: Bioactivity.

target :

TLR3

category :

Proteins and Enzymes

unit sizes :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

110-120 kDa, reducing conditions

theoretical molecular weight :

79.2 kDa

gene symbol :

TLR3

details of functionality :

Measured by its ability to inhibit poly I:C induced IL-8 secretion by HEK293 human embryonic kidney cells transfected with TLR3. The ED50 for this effect is 2-12 µg/mL in the presence of 0.2 µg/mL of poly I:C.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q6PCD4

applications :

Bioactivity

source :

NS0-derived Recombinant Human TLR3 Protein, CF

USD :

377 USD

alt names :

CD283, CD283 antigen, toll-like receptor 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage