Recombinant Human TLR4 Protein, CF | R&D Systems 1478-TR-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TLR4 Protein, CF

catalog :

1478-TR-050

quantity :

50 ug

price :

400 USD

citations: 15

Reference
Khameneh H, Bolis M, Ventura P, Cassanmagnago G, Fischer B, Zenobi A, et al. The bacterial lysate OM-85 engages Toll-like receptors 2 and 4 triggering an immunomodulatory gene signature in human myeloid cells. Mucosal Immunol. 2024;17:346-358 pubmed publisher
Zhang J, Sun Y, Sun C, Shang D. The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice. Bioorg Chem. 2023;132:106376 pubmed publisher
Mayslich C, Grange P, Castela M, Marcelin A, Calvez V, Dupin N. Characterization of a Cutibacterium acnes Camp Factor 1-Related Peptide as a New TLR-2 Modulator in In Vitro and Ex Vivo Models of Inflammation. Int J Mol Sci. 2022;23: pubmed publisher
Kuo H, Lee K, Chen S, Chiu S, Lee L, Chen W, et al. Neuron-Microglia Contacts Govern the PGE2 Tolerance through TLR4-Mediated de Novo Protein Synthesis. Biomedicines. 2022;10: pubmed publisher
He X, Howard B, Liu Y, Neumann A, Li L, Menon N, et al. LYSMD3: A mammalian pattern recognition receptor for chitin. Cell Rep. 2021;36:109392 pubmed publisher
Sun S, Yan Z, Shui X, Qi W, Chen Y, Xu X, et al. Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway. J Cell Mol Med. 2020;24:13104-13114 pubmed publisher
Iannucci A, Caneparo V, Raviola S, Debernardi I, Colangelo D, Miggiano R, et al. Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding. PLoS Pathog. 2020;16:e1008811 pubmed publisher
Shang P, Tang Q, Hu Z, Huang S, Hu Y, Zhu J, et al. Procyanidin B3 alleviates intervertebral disc degeneration via interaction with the TLR4/MD-2 complex. J Cell Mol Med. 2020;24:3701-3711 pubmed publisher
Ito T, Yamamoto S, Yamaguchi K, Sato M, Kaneko Y, Goto S, et al. Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response. J Biol Chem. 2020;295:4014-4023 pubmed publisher
Zheng M, Ambesi A, McKeown Longo P. Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin. Cells. 2020;9: pubmed publisher
Tao C, Cheng K, Ma Y, Hsu W, Chen Y, Fuh J, et al. Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ. 2019;: pubmed publisher
Liu Z, Chen J, Li W, Bi Y, Li Y, Fan M. Identification of FimH derivatives as adjuvant vaccinated with PAc that enhance protection against Streptcoccus mutans colonization. Mol Cell Probes. 2019;45:19-25 pubmed publisher
Knoops B, Becker S, Poncin M, Glibert J, Derclaye S, Clippe A, et al. Specific Interactions Measured by AFM on Living Cells between Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity. Cell Chem Biol. 2018;25:550-559.e3 pubmed publisher
Lee H, Su Y, Huang B, Hsieh F, Chang Y, Tzeng S, et al. Importance of the C-terminal histidine residues of Helicobacter pylori GroES for Toll-like receptor 4 binding and interleukin-8 cytokine production. Sci Rep. 2016;6:37367 pubmed publisher
Loyau J, Malinge P, Daubeuf B, Shang L, Elson G, Kosco Vilbois M, et al. Maximizing the potency of an anti-TLR4 monoclonal antibody by exploiting proximity to FcÎ³ receptors. MAbs. 2014;6:1621-30 pubmed publisher

product information

master code :

1478-TR

SKU :

1478-TR-050

product name :

Recombinant Human TLR4 Protein, CF

unit size :

50 ug

description :

The Recombinant Human TLR4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TLR4 Protein, CF has been validated for the following applications: Bioactivity.

target :

TLR4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

90-95 kDa, reducing conditions

theoretical molecular weight :

70.6 kDa

gene symbol :

TLR4

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human (rh) TLR4 is Immobilized at 2 ╡g/mL (100 ╡L/well), the concentration of rhMD2 that produces 50% optimal binding response is found to be approximately 0.03-0.15 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O00206

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human TLR4 protein Glu24-Lys631, with a C-terminal Ser and 10-His tag

source short :

NS0

USD :

400 USD

alt names :

ARMD10, CD_antigen: CD284, CD284, CD284 antigen, EC 3.2.2.6, EC:3.2.2.6, homolog of Drosophila toll, hToll, TLR4, TLR-4, TOLL, toll like receptor 4 protein, toll-like receptor 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.