Recombinant Human IL-15R alpha Fc Chimera Protein, CF | R&D Systems 147-IR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-15R alpha Fc Chimera Protein, CF

catalog :

147-IR

quantity :

100 ug

price :

339 USD

citations: 9

Reference
Swadling L, Pallett L, Diniz M, Baker J, Amin O, Stegmann K, et al. Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence. Cell Rep. 2020;30:687-698.e6 pubmed publisher
Jones R, Mueller S, O Connor R, Rimpel K, Sloan D, Karel D, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016;12:e1005545 pubmed publisher
Pedroza Pacheco I, Shah D, Domogala A, Luevano M, Blundell M, Jackson N, et al. Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation. Sci Rep. 2016;6:22097 pubmed publisher
Benito Miguel M, García Carmona Y, Balsa A, Bautista Caro M, Arroyo Villa I, Cobo Ibáñez T, et al. IL-15 expression on RA synovial fibroblasts promotes B cell survival. PLoS ONE. 2012;7:e40620 pubmed publisher
Morandi B, Mortara L, Carrega P, Cantoni C, Costa G, Accolla R, et al. NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs. Int Immunol. 2009;21:599-606 pubmed publisher
Eidenschenk C, Jouanguy E, Alcais A, Mention J, Pasquier B, Fleckenstein I, et al. Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. J Immunol. 2006;177:8835-43 pubmed
Miranda Carús M, Benito Miguel M, Llamas M, Balsa A, Martin Mola E. Human T cells constitutively express IL-15 that promotes ex vivo T cell homeostatic proliferation through autocrine/juxtacrine loops. J Immunol. 2005;175:3656-62 pubmed
Giron Michel J, Giuliani M, Fogli M, Brouty Boye D, Ferrini S, Baychelier F, et al. Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors. Blood. 2005;106:2302-10 pubmed
Miranda Carús M, Balsa A, Benito Miguel M, Pérez de Ayala C, Martin Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol. 2004;173:1463-76 pubmed

product information

brand :

R&D Systems

master code :

147-IR

SKU :

147-IR-100

product name :

Recombinant Human IL-15R alpha Fc Chimera Protein, CF

description :

The Recombinant Human IL-15R alpha Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human IL-15R alpha Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-15R alpha

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

51-64 kDa, reducing conditions

theoretical molecular weight :

42.6 kDa (monomer)

gene symbol :

IL15RA

details of functionality :

Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells. Ruchatz, H. et al . (1998) J. Immunol. 160 :5654. The ED50 for this effect is 0.005-0.015 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

147-IR

accessionNumbers :

EAW86418

applications :

Bioactivity

source :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human IL-15 R alpha protein Human IL-15 R alpha (Ile31-Thr172) Accession # EAW86418 IEGRDMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

extended description :

A New IL-15 Ra Available! ~2x better activity; HEK293 expressed; Lower endotoxin specification; No His-tag!

2020 USD :

339

2021 USD :

339 USD

product details :

A New IL-15 Ra Available! ~2x better activity; HEK293 expressed; Lower endotoxin specification; No His-tag!

alt names :

CD215, CD215 antigen, IL15 R alpha, IL-15 R alpha, IL-15 receptor subunit alpha, IL15RA, IL-15RA, IL-15R-alpha, interleukin 15 receptor, alpha, interleukin-15 receptor subunit alpha, MGC104179

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.