Recombinant Human IL-13 R alpha 1 Fc Chimera Protein, CF | R&D Systems 146-IR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-13 R alpha 1 Fc Chimera Protein, CF

catalog :

146-IR-100

quantity :

100 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Stern L, Gholamin S, Moraga I, Yang X, Saravanakumar S, Cohen J, et al. Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy. Proc Natl Acad Sci U S A. 2022;119:e2112006119 pubmed publisher
Brown C, Aguilar B, Starr R, Yang X, Chang W, Weng L, et al. Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. Mol Ther. 2018;26:31-44 pubmed publisher
Miller R, Sadhukhan R, Wu C. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay. J Immunol Methods. 2008;334:134-41 pubmed publisher
Andrews A, Bucchieri F, Arima K, Izuhara K, Holgate S, Davies D, et al. Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q. J Allergy Clin Immunol. 2007;120:91-7 pubmed

product information

brand :

R&D Systems

master code :

146-IR

SKU :

146-IR-100

product name :

Recombinant Human IL-13 R alpha 1 Fc Chimera Protein, CF

description :

The Recombinant Human IL-13 R alpha 1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-13 R alpha 1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

IL-13 R alpha 1

category :

Proteins and Enzymes

unit sizes :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

110 kDa, reducing conditions

theoretical molecular weight :

64 kDa (monomer)

gene symbol :

IL13RA1

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rhIL-13 R alpha 1/Fc Chimera at 4 µg/mL (100 µL/well) can bind rhIL-13 with a linear range of 1-100 ng/mL. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q5JSL4

applications :

Binding Activity

source :

NS0-derived Recombinant Human IL-13 R alpha 1 Fc Chimera Protein, CF

USD :

394 USD

alt names :

bB128O4.2.1 (interleukin 13 receptor, alpha 1), Cancer/testis antigen 19, CD213A1, CD213a1 antigen, CT19, IL13 receptor alpha-1 chain, IL-13 receptor subunit alpha-1, IL13R, IL13R alpha 1, IL-13R subunit alpha-1, IL-13Ra, IL13RA, IL13RA1, IL-13RA1, IL-13R-alpha-1, interleukin 13 receptor, alpha 1, interleukin-13 receptor subunit alpha-1, NR4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage