This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human HTRA2/Omi Protein, CF
catalog :
1458-HT
quantity :
100 ug
price :
339 USD
citations: 5
Reference
Kaur G, Stallmann D, Schanze N, Laumann R, Heger L, Steinfurt J, et al. Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Singh H, Nero T, Wang Y, Parker M, Nie G. Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities. PLoS ONE. 2014;9:e108235 pubmed publisher
Chauhan D, Tian Z, Zhou B, Kuhn D, Orlowski R, Raje N, et al. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res. 2011;17:5311-21 pubmed publisher
Johnson F, Kaplitt M. Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders. PLoS ONE. 2009;4:e7100 pubmed publisher
Huttunen H, GUENETTE S, Peach C, Greco C, Xia W, Kim D, et al. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007;282:28285-95 pubmed
product information
brand :
R&D Systems
master code :
1458-HT
SKU :
1458-HT-100
product name :
Recombinant Human HTRA2/Omi Protein, CF
description :
The Recombinant Human HTRA2/Omi Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human HTRA2/Omi Protein, CF has been validated for the following applications: Enzyme Activity.
target :
HTRA2/Omi
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Supplied as a 0.2 µm filtered solution in HEPES, NaCl, DTT and Glycerol.
conjugate :
Unconjugated
purity :
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
38 kDa, reducing conditions
theoretical molecular weight :
36 kDa
gene symbol :
HTRA2
details of functionality :
Measured by its ability to cleave beta-casein. 95% cleavage of beta-casein, as measured under the described conditions.
catalog number base :
1458-HT
accessionNumbers :
O43464
applications :
Enzyme Activity
source :
E. coli -derived human HTRA2/Omi protein Ala134-Glu458, with a C-terminal 6-His tag
2020 USD :
339
2021 USD :
339 USD
alt names :
High temperature requirement protein A2, HtrA serine peptidase 2, HtrA2, HtrA-like serine protease, Omi, OMIOmi stress-regulated endoprotease, PARK13EC 3.4.21.108, PRSS25, PRSS25serine, 25, Serine protease 25, serine protease HTRA2, mitochondrial, Serine proteinase OMI
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.