product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Decorin Protein, CF
catalog :
143-DE-100
quantity :
100 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 15
Reference
Wang S, Qu Y, Fang X, Ding Q, Zhao H, Yu X, et al. Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-β1. Exp Mol Med. 2023;55:1413-1423 pubmed publisher
Gerhardy S, Ultsch M, Tang W, Green E, Holden J, Li W, et al. Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun. 2022;13:5222 pubmed publisher
Ding Q, Wei Q, Sheng G, Wang S, Jing S, Ma T, et al. The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy. Front Pharmacol. 2021;12:774316 pubmed publisher
Du S, Shao J, Xie D, Zhang F. Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway. PLoS ONE. 2020;15:e0224251 pubmed publisher
Jiang N, Zhang Q, Chau M, Yip M, Lui S, Liu S, et al. Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis. EBioMedicine. 2020;52:102661 pubmed publisher
Kolb A, Shupp A, Mukhopadhyay D, Marini F, Bussard K. Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment. Breast Cancer Res. 2019;21:31 pubmed publisher
Shen Y, Zeglinski M, Turner C, Raithatha S, Wu Z, Russo V, et al. Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing. Exp Mol Med. 2018;50:68 pubmed publisher
Gogalic S, Sauer U, Doppler S, Preininger C. Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer. Biosensors (Basel). 2018;8: pubmed publisher
Ishikawa Y, Holden P, Bachinger H. Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum. J Biol Chem. 2017;292:17216-17224 pubmed publisher
Kelc R, Trapecar M, Gradisnik L, Rupnik M, Vogrin M. Platelet-rich plasma, especially when combined with a TGF-β inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro. PLoS ONE. 2015;10:e0117302 pubmed publisher
Rottenberger Z, Komorowicz E, Szabó L, Bóta A, Varga Z, Machovich R, et al. Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. J Thromb Haemost. 2013;11:529-38 pubmed publisher
Zhang Y, Conrad A, Conrad G. Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking. J Biol Chem. 2011;286:13011-22 pubmed publisher
Kitaya K, Yasuo T. Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium. J Leukoc Biol. 2009;85:391-400 pubmed publisher
Bolton K, Segal D, McMillan J, Jowett J, Heilbronn L, Abberton K, et al. Decorin is a secreted protein associated with obesity and type 2 diabetes. Int J Obes (Lond). 2008;32:1113-21 pubmed publisher
Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
143-DE
SKU :
143-DE-100
product name :
Recombinant Human Decorin Protein, CF
Description :
The Recombinant Human Decorin Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Decorin Protein, CF has been validated for the following applications: Bioactivity.
target :
Decorin
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
40-42 kDa, reducing conditions
theoretical molecular weight :
38 kDa
gene symbol :
DCN
details of functionality :
Measured by its ability to modulate collagen fibrillogenesis. Ge, G. et al . (2004) J. Biol. Chem. 279 :41626. At 5 µg/mL, Recombinant Human Decorin can significantly delay the rate of type I collagen fibrillogenesis.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P07585
applications :
Bioactivity
source :
Sf 21 (baculovirus)-derived Recombinant Human Decorin Protein
USD :
400 USD
alt names :
Bone proteoglycan II, CSCD, DCN, decorin, decorin proteoglycan, dermatan sulphate proteoglycans II, DSPG2, PG40, PGII, PG-II, PGS2, PG-S2, proteoglycan core protein, SLRR1B, SLRR1BPGS2, small leucine-rich protein 1B
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.