Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF | R&D Systems 142-DC-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF

catalog :

142-DC-100

quantity :

100 ug

price :

458 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Zwolak A, Chan S, Harvilla P, Mahady S, Armstrong A, Luistro L, et al. A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3. Sci Rep. 2022;12:20538 pubmed publisher
Peng Y, Peng C, Lin Y, Lin G, Huang S, Chen S, et al. Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway. Mediators Inflamm. 2020;2020:1237281 pubmed publisher
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Connor J, Felder M, Kapur A, Onujiogu N. DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1. BMC Cancer. 2012;12:176 pubmed publisher
Tso G, Law H, Tu W, Chan G, Lau Y. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells. 2010;28:939-54 pubmed publisher
Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, et al. Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy. Biomaterials. 2010;31:3357-63 pubmed publisher
Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, et al. Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients. Leukemia. 2009;23:2139-46 pubmed publisher
Mueller A, Pedre X, Killian S, David M, Steinbrecher A. The Decoy Receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid. J Neuroimmunol. 2009;209:57-64 pubmed publisher
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 2007;178:192-200 pubmed
Edwards J, Sun S, Locklin R, Shipman C, Adamopoulos I, Athanasou N, et al. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum. 2006;54:1451-62 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

142-DC

SKU :

142-DC-100

product name :

Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF

Description :

The Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

DcR3/TNFRSF6B

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

60-65 kDa, reducing conditions

theoretical molecular weight :

57 kDa (monomer)

gene symbol :

TNFRSF6B

details of functionality :

Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. Cheng, J. et al . (1994) Science 263 :1759. The ED50 for this effect is 0.03-0.15 µg/mL in the presence of 20 ng/mL rhFas Ligand.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O95407

applications :

Bioactivity

source :

Sf 21 (baculovirus)-derived Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein

USD :

458 USD

alt names :

DCR3Decoy receptor for Fas ligand, Decoy receptor 3, M68, M68DJ583P15.1.1, TNFRSF6B, TR6, TR6DcR3, tumor necrosis factor receptor superfamily member 6B, tumor necrosis factor receptor superfamily, member 6b, decoy

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage