product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human B7-2/CD86 Fc Chimera Protein, CF
catalog :
141-B2-100
quantity :
100 ug
price :
377 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Sic H, Speletas M, Cornacchione V, Seidl M, Beibel M, Linghu B, et al. An Activating Janus Kinase-3 Mutation Is Associated with Cytotoxic T Lymphocyte Antigen-4-Dependent Immune Dysregulation Syndrome. Front Immunol. 2017;8:1824 pubmed publisher
Douthwaite J, Moisan J, Privezentzev C, Soskic B, Sabbah S, Cohen S, et al. A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding. J Immunol. 2017;198:528-537 pubmed
Choi J, Goh G, Walradt T, Hong B, Bunick C, Chen K, et al. Genomic landscape of cutaneous T cell lymphoma. Nat Genet. 2015;47:1011-9 pubmed publisher
Sakthivel P, Shively V, Kakoulidou M, Pearce W, Lefvert A. The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm. J Intern Med. 2007;261:399-407 pubmed
product information
brand :
R&D Systems
master code :
141-B2
SKU :
141-B2-100
product name :
Recombinant Human B7-2/CD86 Fc Chimera Protein, CF
description :
The Recombinant Human B7-2/CD86 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human B7-2/CD86 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
B7-2/CD86
category :
Proteins and Enzymes
sizes available :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
85-95 kDa, reducing conditions
theoretical molecular weight :
52.7 kDa (monomer)
gene symbol :
CD86
details of functionality :
Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells. Freeman, G.J. et al . (1993) Science 262 :909. The ED50 for this effect is 0.2-0.8 µg/mL in the presence of PHA.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAB03814
applications :
Bioactivity
extended description :
A New rh B7-2 is Available! It has higher purity, ~3 fold better activity, and is HEK293 expressed!
source :
NS0-derived Recombinant Human B7-2/CD86 Fc Chimera Protein, CF
USD :
377
USD 2023 :
377 USD
product details :
A New rh B7-2 is Available! It has higher purity, ~3 fold better activity, and is HEK293 expressed!
alt names :
Activation B7-2 antigen, B70, B72, B7-2, B7-2 antigen, B-lymphocyte activation antigen B7-2, BU63, CD28 antigen ligand 2, CD28LG2B7-2 antigen), CD86, CD86 antigen, CD86 molecule, CTLA-4 counter-receptor B7.2, FUN-1, LAB72, MGC34413, T-lymphocyte activation antigen CD86
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.