Recombinant Human Cystatin A Protein, CF | R&D Systems 1407-PI-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cystatin A Protein, CF

catalog :

1407-PI-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Chang K, Wu C, Chen H, Chen S, Peng P, Tsang N, et al. Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: potential usage of cystatin A for predicting nodal stage and poor prognosis. Proteomics. 2010;10:2644-60 pubmed publisher
Chang S, Kanasaki K, Gocheva V, Blum G, Harper J, Moses M, et al. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res. 2009;69:4537-44 pubmed publisher
Feldman A, Banyard J, Wu C, McDougal W, Zetter B. Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res. 2009;15:1024-31 pubmed publisher
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
Johnson G, Jiang W. Characterization of cathepsin L secreted by Sf21 insect cells. Arch Biochem Biophys. 2005;444:7-14 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1407-PI

SKU :

1407-PI-050

product name :

Recombinant Human Cystatin A Protein, CF

Description :

The Recombinant Human Cystatin A Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Cystatin A Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Cystatin A

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

12 kDa, reducing conditions

theoretical molecular weight :

12 kDa

gene symbol :

CSTA

details of functionality :

Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC (Catalog # ES009 ). The IC50 value is 3.4 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P01040

applications :

Inhibition Activity

source :

E. coli-derived Recombinant Human Cystatin A Protein

USD :

423 USD

alt names :

AREI, CSTA, cystatin A (stefin A), cystatin AS, cystatin-A, Stefin A, STF1, STF1Cystatin-AS, STFA, STFAStefin-A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage