product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human SOST/Sclerostin Protein
catalog :
1406-ST-025
quantity :
25 ug
price :
396 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Ruscitto A, Chen P, Tosa I, Wang Z, Zhou G, Safina I, et al. Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell Stem Cell. 2023;30:1179-1198.e7 pubmed publisher
Kurgan N, Baranowski B, Stoikos J, MacNeil A, Fajardo V, Macpherson R, et al. Characterization of sclerostin's response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice. Front Physiol. 2022;13:1061715 pubmed publisher
Gronbach M, Mitrach F, Moller S, Rother S, Friebe S, Mayr S, et al. A Versatile Macromer-Based Glycosaminoglycan (sHA3) Decorated Biomaterial for Pro-Osteogenic Scavenging of Wnt Antagonists. Pharmaceutics. 2020;12: pubmed publisher
Ohori F, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Qi J, et al. Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement. J Immunol Res. 2019;2019:9716758 pubmed publisher
Nguyen Yamamoto L, Tanaka K, St Arnaud R, Goltzman D. Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification. JCI Insight. 2019;4: pubmed publisher
Dole N, Mazur C, Acevedo C, Lopez J, Monteiro D, Fowler T, et al. Osteocyte-Intrinsic TGF-? Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling. Cell Rep. 2017;21:2585-2596 pubmed publisher
Shu R, Bai D, Sheu T, He Y, Yang X, Xue C, et al. Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement. PLoS ONE. 2017;12:e0167312 pubmed publisher
Kogawa M, Wijenayaka A, Ormsby R, Thomas G, Anderson P, Bonewald L, et al. Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2. J Bone Miner Res. 2013;28:2436-48 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Appel H, Ruiz Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, et al. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum. 2009;60:3257-62 pubmed publisher
Jager A, Gotz W, Lossdörfer S, Rath Deschner B. Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro. J Periodontal Res. 2010;45:246-54 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
1406-ST
SKU :
1406-ST-025
product name :
Recombinant Human SOST/Sclerostin Protein
Description :
The Recombinant Human SOST/Sclerostin Protein from R&D Systems is derived from NS0. The Recombinant Human SOST/Sclerostin Protein has been validated for the following applications: Bioactivity.
target :
SOST/Sclerostin
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
28-32 kDa, reducing conditions
theoretical molecular weight :
22.5 kDa
gene symbol :
SOST
details of functionality :
Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 1.5-6 µg/mL in the presence of 3 ng/mL Recombinant Mouse Wnt-3a (Catalog # 1324-WN ).
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9BQB4
applications :
Bioactivity
source :
NS0-derived Recombinant Human SOST/Sclerostin Protein
USD :
396 USD
alt names :
sclerostin, VBCHsclerosteosis
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.